1582221-33-7

Basic information

• Product Name: ethyl 2-(4-bromophenyl)-5-phenyloxazole-4-carboxylate
• Synonyms: ethyl 2-(4-bromophenyl)-5-phenyloxazole-4-carboxylate
• CAS NO: 1582221-33-7
• Molecular Weight: 372.218
• Mol File: 1582221-33-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-bromophenyl)-5-phenyloxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-bromophenyl)-5-phenyloxazole-4-carboxylate(1582221-33-7)
• EPA Substance Registry System: ethyl 2-(4-bromophenyl)-5-phenyloxazole-4-carboxylate(1582221-33-7)

Safety Data

• Hazardous Substances Data: 1582221-33-7(Hazardous Substances Data)

Upstream product

• 3959-07-7 4-Bromobenzylamine 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 391248-23-0 ethyl 2-(4-bromphenyl)-1,3-oxazole-4-carboxylate 
• 515-42-4 sodium phenylsulfonate 
• 2216-94-6 phenylpropynoic acid ethyl ester 

Relevant articles and documents

NIS-TBHP promoted oxidative coupling of C–N and C–O bonds: A metal-free approach to polysubstituted oxazoles

A metal-free approach to polysubstituted oxazoles via the oxidative coupling of readily available benzylamines and 1,3-dicarbonyl derivatives in the presence of an external base has been developed. A variety of functional groups on both of the starting materials are tolerated using this method, affording the corresponding oxazoles in moderate to good yields. Iodination was proposed as the initiation step of the reaction and a plausible mechanism has been proposed to explain the reaction pathway.

Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source. This journal is the Partner Organisations 2014.