158262-82-9Relevant articles and documents
Synthesis of a new transition-state analog of the sialyl donor. Inhibition of sialyltransferases
Sun, Hongbin,Yang, Jingsong,Amaral, Katie E.,Horenstein, Benjamin A.
, p. 2451 - 2453 (2001)
A new class of glycosyltransferase inhibitor has been designed and synthesized. The designed inhibitors 3a/3b provide conformational mimicry of the transition state in sialyltransfer reactions. The key synthetic steps involve a Meinwald rearrangement and a palladium-catalyzed carbonylation reaction. The results of kinetic studies show that 3a/3b exhibit significant inhibition on both 2,3- and 2,6-sialytransferases.