158276-23-4 Usage
General Description
H-LYS(NICOTINOYL)-OH HCL is a chemical compound that consists of the amino acid lysine that has been modified with a nicotinoyl group and is in its hydrochloride salt form. Lysine is an essential amino acid that plays a crucial role in protein synthesis and the maintenance of overall health. The addition of the nicotinoyl group to lysine may provide additional functional properties, as nicotinamide is known to be involved in various metabolic processes, such as energy production and DNA repair. The hydrochloride salt form of H-LYS(NICOTINOYL)-OH may be more soluble and stable in aqueous solutions, making it easier to handle and use in experimental and industrial applications. Overall, H-LYS(NICOTINOYL)-OH HCL is a compound with potential biological and chemical properties that make it suitable for a variety of research and industrial purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 158276-23-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,2,7 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 158276-23:
(8*1)+(7*5)+(6*8)+(5*2)+(4*7)+(3*6)+(2*2)+(1*3)=154
154 % 10 = 4
So 158276-23-4 is a valid CAS Registry Number.
158276-23-4Relevant articles and documents
Novel, Potent Luteinizing Hormone-Releasing Hormone Antagonists with Improved Solubility in Water
Janecka, Anna,Janecki, Tomasz,Shan, Si-mei,Bowers, Cyril,Folkers, Karl
, p. 2238 - 2241 (1994)
A series of luteinizing hormone-releasing hormone antagonists with new substitutions in position 6 or positions 5 and 6 that included lysine acylated at the ε-amino group with different heterocyclic carboxylic acids or amino-substituted heterocyclic carboxylic acids was synthesized.These novel analogs were synthesized on a solid-phase support via the acylation of lysine residue in otherwise protected resin-bound peptides.All analogs were tested in the rat antiovulatory assay (AOA) and the best of them in in vitro histamine release assay.Introduction of lusine acylated with amino-substituted heterocyclic carboxylic acids yielded several water-soluble antagonists with good therapeutic ratio (high AOA to low histamine releasing activity).The best antagonist in terms of activity, histamine release, and solubility was nictide: NAcDNal-DCpa-DPal-Ser-PicLys-D(6ANic)-Orn-Leu-ILys-Pro-DAlaNH2 (6ANic = 6-aminonicotinoyl).
