1582793-06-3Relevant articles and documents
Enantioselective Cu-catalyzed decarboxylative propargylic amination of propargyl carbamates
Zou, Yuan,Zhu, Fu-Lin,Duan, Zheng-Chao,Wang, Ya-Hui,Zhang, De-Yang,Cao, Zhong,Zheng, Zhuo,Hu, Xiang-Ping
supporting information, p. 2033 - 2036 (2014/04/03)
A copper-catalyzed asymmetric propargylic amination with a chiral ketimine P,N,N-ligand that proceeds via decarboxylation of propargyl carbamates has been developed. The reaction can be performed under the mild condition for a broad range of substrates, providing the corresponding propargylic amines in high yields and with up to 97% ee. This reaction represents a new and facile access to optically active propargylic amines.