1584-62-9 Usage
Description
2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide, also known as N-[2-(2-Fluorophenyl)-4-chlorophenyl-2-bromoacetamide (CAS# 1584-62-9), is a light yellow solid compound with a unique molecular structure. It is characterized by the presence of a bromo, chloro, and fluoro substituents on its aromatic rings, which contribute to its chemical properties and potential applications in various fields.
Uses
Used in Organic Synthesis:
2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a valuable building block for the development of new molecules with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide is used as a key component in the development of new drugs. Its structural diversity and the presence of multiple functional groups make it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Chemical Research:
2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide is also utilized in chemical research for studying the reactivity and behavior of different functional groups. Its unique structure provides an opportunity to explore various reaction pathways and mechanisms, contributing to the advancement of chemical knowledge and understanding.
Used in Material Science:
In the field of material science, 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide can be employed as a component in the development of new materials with specific properties. Its structural features may contribute to the creation of materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1584-62-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,8 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1584-62:
(6*1)+(5*5)+(4*8)+(3*4)+(2*6)+(1*2)=89
89 % 10 = 9
So 1584-62-9 is a valid CAS Registry Number.
1584-62-9Relevant articles and documents
Axially chiral Ni(II) complexes of α-amino acids: Separation of enantiomers and kinetics of racemization
Zhang, Wenzhong,Ekomo, Romuald Eto,Roussel, Christian,Moriwaki, Hiroki,Abe, Hidenori,Han, Jianlin,Soloshonok, Vadim A.
, p. 498 - 508 (2018)
Herein we present design, synthesis, chiral HPLC resolution, and kinetics of racemization of axially chiral Ni(II) complexes of glycine and di-(benzyl)glycine Schiff bases. We found that while the ortho-fluoro derivatives are configurationally unstable, t
Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists
Bolli, Martin H.,Marfurt, Judith,Grisostomi, Corinna,Boss, Christoph,Binkert, Christoph,Hess, Patrick,Treiber, Alexander,Thorin, Eric,Morrison, Keith,Buchmann, Stephan,Bur, Daniel,Ramuz, Henri,Clozel, Martine,Fischli, Walter,Weller, Thomas
, p. 2776 - 2795 (2007/10/03)
Since its discovery in 1988 by Yanagisawa et al., endothelin (ET), a potent vasoconstrictor, has been widely implicated in the pathophysiology of cardiovascular, cerebrovascular, and renal diseases. Many research groups have embarked on the discovery and development of ET receptor antagonists for the treatment of such diseases. While several compounds, e.g., ambrisentan 2, are in late clinical trials for various indications, one compound (bosentan, Tracleer) is being marketed to treat pulmonary arterial hypertension. Inspired by the structure of ambrisentan 2, we designed a novel class of ET receptor antagonists based on a 1,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-one scaffold. Here, we report on the preparation as well as the in vitro and in vivo structure-activity relationships of these derivatives. Potent dual ET A/ETB receptor antagonists with affinities in the low nanomolar range have been identified. In addition, several compounds efficiently reduced arterial blood pressure after oral administration to Dahl salt sensitive rats. In this animal model, the efficacy of the benzo[e] [1,4]diazepin-2-one derivative rac-39au was superior to that of racemic ambrisentan, rac-2.