1585241-82-2

Basic information

• Product Name: (2R,3S,4S)-1-benzyl 2-tert-butyl 3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-1,2-dicarboxylate
• Synonyms: (2R,3S,4S)-1-benzyl 2-tert-butyl 3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-1,2-dicarboxylate
• CAS NO: 1585241-82-2
• Molecular Weight: 542.586
• Mol File: 1585241-82-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3S,4S)-1-benzyl 2-tert-butyl 3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4S)-1-benzyl 2-tert-butyl 3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-1,2-dicarboxylate(1585241-82-2)
• EPA Substance Registry System: (2R,3S,4S)-1-benzyl 2-tert-butyl 3-(2-methoxy-2-oxoethyl)-4-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)pyrrolidine-1,2-dicarboxylate(1585241-82-2)

Safety Data

• Hazardous Substances Data: 1585241-82-2(Hazardous Substances Data)

Upstream product

• 1585241-81-1 C₄₀H₃₉O₄P 
• 1585241-68-4 5-benzhydryl 1-tert-butyl 2-oxopentanedioate 
• 1585241-69-5 (S)-5-benzhydryl 1-tert-butyl 3-((S)-1-(2-methoxy-6-(methoxycarbonyl)pyridin-3-yl)-2-nitroethyl)-2-oxopentanedioate 
• 1585241-70-8 C₃₂H₃₆N₂O₇ 
• 1585241-71-9 methyl 5-((3S,4S,5R)-5-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)pyrrolidin-3-yl)-6-methoxypicolinate 
• 501-53-1 benzyl chloroformate 
• 2402-78-0 2,6-dichloropyridine 
• 17228-64-7 6-chloro-2-methoxypyridine 
• 95652-81-6 6-chloro-2-methoxy-3-pyridinecarboxaldehyde 
• 401792-87-8 methyl 5-formyl-6-methoxy-2-pyridinecarboxylate 

Downstream Products

• 1585241-72-0 C₂₄H₂₆N₂O₉ 
• 86630-09-3 Acromelic acid A 

Relevant articles and documents

Practical total syntheses of acromelic acids A and B

Practical total syntheses of acromelic acids A (1) and B (2), which were scarce natural products isolated from toxic mushroom by Shirahama and Matsumoto, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), respectively, from 2,6-dichloropyridine (8). Beginning with regioselective transformation of symmetric 8 by either ortho-lithiation or bromination, nitroalkenes 15 and 16 were provided. Stereoselective construction of the vicinal stereocenters at the C-3, 4 positions of 1 and 2 was performed by a Ni-catalyzed asymmetric conjugate addition of α-ketoesters to the nitroalkenes. Construction of the pyrrolidine ring was accomplished in a single operation via a sequence consisting of reduction of the nitro group, intramolecular condensation with the ketone, and reduction of the resulting ketimine.