15854-73-6

Basic information

• Product Name: 4-METHOXY-3-NITROBIPHENYL
• Synonyms: 3-NITRO-4-METHOXYBIPHENYL;4-METHOXY-3-NITROBIPHENYL;4-METHOXY-3-NITROBIPHENYL 99+%;2-NITRO-4-PHENYLANISOLE
• CAS NO: 15854-73-6
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23
• Mol File: 15854-73-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 90-91°C
• Boiling Point: 383.5°C at 760 mmHg
• Flash Point: 174.2°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 9.64E-06mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-METHOXY-3-NITROBIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-3-NITROBIPHENYL(15854-73-6)
• EPA Substance Registry System: 4-METHOXY-3-NITROBIPHENYL(15854-73-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 15854-73-6(Hazardous Substances Data)

Usage

General Description

4-Methoxy-3-nitrobiphenyl, also known as 3-nitro-4-methoxybiphenyl, is a chemical compound that consists of a biphenyl ring with a methoxy (CH3O) group in the para position and a nitro (NO2) group in the meta position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The chemical is primarily used as a building block for the development of various products and has a wide range of applications. It is important to handle this compound with caution, as it is considered to be toxic and harmful if swallowed, inhaled, or in contact with skin. Additionally, it is a potential environmental hazard and should be properly handled and disposed of in accordance with regulations.

InChI:InChI=1/C13H11NO3/c1-17-13-8-7-11(9-12(13)14(15)16)10-5-3-2-4-6-10/h2-9H,1H3

Upstream product

• 33696-00-3 4-bromo-1-methoxy-2-nitrobenzene 
• 934-56-5 trimethyl(phenyl)stannane 
• 960-16-7 tributylphenylstannane 
• 613-37-6 4-methoxylbiphenyl 
• 98-80-6 phenylboronic acid 
• 92-69-3 4-Phenylphenol 
• 27701-66-2 4-bromo-3-nitrobiphenyl 
• 124-41-4 sodium methylate 
• 885-82-5 4-phenyl-2-nitrophenol 
• 616-38-6 carbonic acid dimethyl ester 
• 7693-52-9 4-bromo-2-nitrophenol 
• 108-86-1 bromobenzene 
• 74-88-4 methyl iodide 
• 7697-37-2 nitric acid 

Downstream Products

• 39811-17-1 5-phenyl-O-anisidine 
• 149877-41-8 bifenazate 

Relevant articles and documents

Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle

An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500–1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.

Synthetic method for bifenazate

The invention relates to a synthetic method for bifenazate. The method comprises the following specific synthetic sections: step 1, performing nitration: mixing a 4-hydroxybiphenyl solution and a toluene solution under stirring for a reaction, and adding a HNO3 solution dropwise for a reaction to obtain a nitration reaction solution; step 2, performing methylation: mixing the nitration reaction solution and anhydrous sodium carbonate powder for a reaction, and adding a dimethyl carbonate solution dropwise for a reaction to obtain a methylation reaction solution; step 3, performing hydrogenation: throwing the methylation reaction solution, hydrogen gas, and Raney nickel into a reaction kettle for a reaction to obtain a hydrogenation reaction liquid; step 4, performing hydrazination: performing a primary hydrazination reaction, performing a secondary hydrazination reaction, performing filter pressing, performing a tertiary hydrazination reaction, and performing secondary filter pressingto obtain a condensation reaction liquid; step 5, performing condensation: mixing a third hydrazine compound, an ethyl acetate solution and an isopropyl chloroformate solution for a reaction to obtaina bifenazate mixed liquid; and step 6, performing purification: performing desolvation, performing crystallization, performing centrifugation, performing washing, performing secondary centrifugation,and performing drying to obtain the finished bifenazate. The method provided by the invention has the effect of improving purity of the bifenazate product.

Sulfonamide compound and medical applications thereof

The invention discloses a compound containing a sulfonamide structure, a preparation method thereof, and medical applications of the compound, and more specifically discloses the compound with a structure represented by formula I, and a pharmaceutically acceptable salt or a prodrug or a solvate thereof. The compound is used for tumor treatment through inhibiting ATP-citrate lyase.