158584-99-7

Basic information

• Product Name: Benzaldehyde, 2-bromo-3-(phenylmethoxy)-
• Synonyms: 3-(benzyloxy)-2-bromobenzaldehyde;Benzaldehyde,2-bromo-3-(phenylmethoxy);2-bromo-3-benzyloxybenzaldehyde
• CAS NO: 158584-99-7
• Molecular Formula: C14H11BrO2
• Molecular Weight: 291.144
• Mol File: 158584-99-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-bromo-3-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-bromo-3-(phenylmethoxy)-(158584-99-7)
• EPA Substance Registry System: Benzaldehyde, 2-bromo-3-(phenylmethoxy)-(158584-99-7)

Safety Data

• Hazardous Substances Data: 158584-99-7(Hazardous Substances Data)

Upstream product

• 196081-71-7 2-bromo-3-hydroxy-benzaldehyde 
• 100-39-0 benzyl bromide 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1700-30-7 (3-(benzyloxy)phenyl)methanol 
• 158585-00-3 2-bromo-3-benzyloxy-benzyl alcohol 
• 1700-37-4 3-Benzyloxybenzaldehyde 

Downstream Products

• 870288-28-1 1-(3-benzyloxy-2-bromo-phenyl)-ethanol 
• 159425-38-4 2-<2-bromo-3-(benzyloxy)phenyl>-1,3-dioxane 
• 856906-43-9 1-(3-(benzyloxy)-2-bromophenyl)ethan-1-one 

Relevant articles and documents

Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions

A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta

Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum (ER) resident isoform of the 90 kDa heat shock protein (Hsp90) family and its inhibition represents a promising therapeutic target for the treatment of many diseases. Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity. Structure–activity relationship studies led to the discovery of compound 30, which exhibits 540 nm affinity and 73-fold selectivity towards Grp94. Grp94 is responsible for the maturation and trafficking of proteins associated with cell signaling and motility, including select integrins. The Grp94-selective inhibitor 30 was shown to exhibit potent anti-migratory effects against multiple aggressive and metastatic cancers.

NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicaments.