15865-94-8

Basic information

• Product Name: 2-Thiazolamine, 4,5-dimethyl-N-phenyl-
• CAS NO: 15865-94-8
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.296
• Mol File: 15865-94-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, 4,5-dimethyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, 4,5-dimethyl-N-phenyl-(15865-94-8)
• EPA Substance Registry System: 2-Thiazolamine, 4,5-dimethyl-N-phenyl-(15865-94-8)

Safety Data

• Hazardous Substances Data: 15865-94-8(Hazardous Substances Data)

Upstream product

• 142-04-1 aniline hydrochloride 
• 62-53-3 aniline 
• 57308-65-3 3-thiocyanobutan-2-one 
• 71-43-2 benzene 
• 78-93-3 butanone 
• 1226922-89-9 C₅H₅N*C₇H₇NS₂ 
• 51034-34-5 potassium aniline dithiocarbamate 
• 1074-52-8 ammonium phenyldithiocarbamate 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 43009-16-1 phenyldithiocarbamic acid triethylamine salt 
• 56355-41-0 2-chloro-4,5-dimethyl-1,3-thiazole 
• 103-85-5 monophenylthiourea 
• 4091-39-8 3-chloro-2-butanone 

Downstream Products

• 2211-44-1 (1H-benzoimidazol-2-ylmethyl)-(4,5-dimethyl-thiazol-2-yl)-phenyl-amine 
• 208396-25-2 phenyl-(3,4,5-trimethyl-3H-thiazol-2-ylidene)-amine 

Relevant articles and documents

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Expedient synthesis of N-substituted 2-aminothiazoles

The reaction of α-halo ketones 1 with potassium thiocyanate and amines 3 offers the advantage of an efficient one-pot synthesis of the title compounds 4 from readily available starting materials.