158665-14-6

Basic information

• Product Name: 2-amino-6-(4-chlorophenylsulfanyl)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
• Synonyms: 2-amino-6-(4-chlorophenylsulfanyl)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
• CAS NO: 158665-14-6
• Molecular Weight: 535.965
• Mol File: 158665-14-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-6-(4-chlorophenylsulfanyl)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-(4-chlorophenylsulfanyl)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine(158665-14-6)
• EPA Substance Registry System: 2-amino-6-(4-chlorophenylsulfanyl)-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine(158665-14-6)

Safety Data

• Hazardous Substances Data: 158665-14-6(Hazardous Substances Data)

Upstream product

• 6979-94-8 2',3',5'-tri-O-acetyl-guanosine 
• 16321-99-6 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 158665-18-0 2-amino-6-(4-chlorophenylthio)-(2,3-O-isopropylidene-β-D-ribofuranosyl)purine 
• 158665-16-8 9-<(2-acetoxyethoxy)methyl>-2-amino-6-(4-chlorophenylthio)-9H-purine 
• 84408-37-7 deoxyacyclovir 
• 172324-62-8 9--6-(4-chlorophenylsulfanyl)-2-(phenylacetamido)-9H-purine 
• 172324-61-7 9--2-N-(phenylacetyl)guanine 
• 172324-60-6 9--2-N-(phenylacetyl)guanine 
• 1026560-19-9 6-(4-chlorophenylsulfanyl)-2-(phenylacetamido)-9H-purine 
• 125962-37-0 9-guanine 
• 158665-15-7 2-amino-6-<(4-chlorophenyl)sulfanyl>purine 

Relevant articles and documents

Conversion of guanosine into acyclovir and its 6-deoxy derivative

2-amino-6-(4-chlorophenylthio)-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl) purine 11, which is readily prepared by allowing the corresponding 6-chloro-compound 10 to react with 4-chloro(thiophenol) and triethylamine in methanol solution at room temperature, reacts with boron trifluoride diethyl etherate in boiling dichloromethane solution to give 2-amino-6-(4-chlorophenylthio)-9H-purine 12 in high isolated yield. 9-[(2-acetoxyethoxy)methyl]-2-amino-6-(4-chlorophenylthio)-9H-purine 13, prepared from the latter aglycone 12 in good yield, is converted by a four-step process into acyclovir 1 and by a two-step process into 6-deoxyacyclovir 2.