158692-57-0

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 2-chloro-5-phenyl-, ethyl ester
• CAS NO: 158692-57-0
• Molecular Formula: C13H12ClNO2
• Molecular Weight: 249.697
• Mol File: 158692-57-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 2-chloro-5-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 2-chloro-5-phenyl-, ethyl ester(158692-57-0)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 2-chloro-5-phenyl-, ethyl ester(158692-57-0)

Safety Data

• Hazardous Substances Data: 158692-57-0(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 105-56-6 ethyl 2-cyanoacetate 
• 22984-74-3 Ethyl 2-cyano-4-oxo-4-phenylbutanoate 

Downstream Products

• 881673-95-6 (5-phenyl-1H-pyrrol-3-yl)methanol 
• 881676-54-6 1-{[3-(methylsulfonyl)phenyl]sulfonyl}-5-phenyl-1H-pyrrole-3-carbaldehyde 
• 881676-06-8 5-phenyl-1-(2-thienylsulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881676-90-0 5-phenyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881676-92-2 1-[(6-methoxypyridin-3-yl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde 
• 881673-96-7 tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]-carbamate 
• 881678-28-0 tert-butyl ({[1-(6-chloropyridin-3-yl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)methylcarbamate 
• 1374671-92-7 tert-butyl ({[1-(6-cyanopyridin-3-yl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methyl)methylcarbamate 
• 56448-22-7 5-phenyl-1H pyrrole-3-carboxaldehyde 
• 881676-04-6 5-phenyl-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde 
• 881675-20-3 ethyl 1-(imidazo[1,2-a]pyrimidin-6-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carboxylate 
• 881675-18-9 ethyl 1-[(2-amino-5-pyrimidine)sulfonyl]-5-phenyl-1H-pyrrole-3-carboxylate 

Relevant articles and documents

Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3- ylsulfonyl)-1 H -pyrrol-3-yl]- n -methylmethanamine fumarate (tak-438) as a Potassium-Competitive Acid Blocker (P-CAB)

In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log"‰D and high ligand-lipophilicity efficiency (LLE) values. Among the compounds synthesized, the compound 13e exhibited potent H +,K+-ATPase inhibitory activity and potent gastric acid secretion inhibitory action in vivo. Its maximum efficacy was more potent and its duration of action was much longer than those of proton pump inhibitors (PPIs). Therefore, compound 13e (1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)- 1H-pyrrol-3-yl]-N-methylmethanamine fumarate, TAK-438) was selected as a drug candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases.

ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS

The present invention relates to novel arylpiperazine-containing pyrrole 3-carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof which is useful for preventing or treating depressive disorders. The present invention also provides a method for preparing the arylpiperazine-containing pyrrole 3-carboxamide derivatives or the pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating depressive disorders.