158705-89-6

Basic information

• Product Name: (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile
• Synonyms: (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile
• CAS NO: 158705-89-6
• Molecular Weight: 193.202
• Mol File: 158705-89-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile(158705-89-6)
• EPA Substance Registry System: (R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile(158705-89-6)

Safety Data

• Hazardous Substances Data: 158705-89-6(Hazardous Substances Data)

Upstream product

• 74-90-8 hydrogen cyanide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 151-50-8 potassium cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 6309-18-8 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile 

Downstream Products

• 158666-69-4 (R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile 
• 158705-92-1 (1S,2R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-dimethoxyphenyl)-phenylethylamine 
• 158705-93-2 (1'S,2'R)-(-)-N-<2-(tert-butyldiphenylsilyloxy)-2-(3,4-dimethoxyphenyl)-1-phenylethyl>acetamide 
• 158705-94-3 (3S,4R)-(-)-4-(tert-butyldiphenylsilyloxy)-6,7-dimethoxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline 
• 158705-96-5 (1R,3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 158705-95-4 (3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline 

Relevant articles and documents

Novel (R)-oxynitrilase sources for the synthesis of (R)-cyanohydrins in diisopropyl ether

Apple, apricot, cherry and plum meal were prepared from the seeds or kernels of mature garden fruits. The preparations as well as almond meal were used as the source of (R)-oxynitrilase for the synthesis of aliphatic and aromatic cyanohydrins in diisoprop

Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes

The chiral vicinal C-O/C-N bifunctional groups generated from enzymatic hydrocyanation represents a useful methodology. However, construction of the pharmacophore of β2-adrenoreceptor agonists with this method remains a great challenge because of complete racemization of the benzylic alcohol during deprotection of the acetal groups. In this study, structure-guided redesign of a hydroxynitrile lyase originating from Prunus communis (PcHNL5) enables a highly enantioselective hydrocyanation of rigid benzo-ketal aldehyde which was proved to be resistant against racemization during the deprotection step, with dramatically improved productivity (>95% conversion vs 2-adrenoreceptor agonist, in an optically pure form (>99% ee) with an overall yield of 54%, which is the highest value reported.

(R)- and (S)-cyanohydrins using oxynitrilases in whole cells

Almond meal and Sorghum bicolor shoots were used as the sources of oxynitrilases for the preparation of a number (R)- and (S)-arylcyanohydrins, respectively, from the corresponding aldehydes in diisopropyl ether. Two different in situ methods were used to introduce hydrogen cyanide into the reaction mixture. In method 1, acetone cyanohydrin decomposes enzymatically and/or chemically to hydrogen cyanide. In method 2, hydrogen cyanide freely evaporates from a solution in diisopropyl ether from one compartment of the reaction vessel and ends up to the other where it dissolves into the reaction mixture.