158811-19-9Relevant articles and documents
Taxol Chemistry. 7-O-Triflates as Precursors to Olefins and Cyclopropanes
Johnson, Roy A.,Nidy, Eldon G.,Dobrowolski, Paul J.,Gebhard, Ilse,Qualls, Samuel J.,et al.
, p. 7893 - 7896 (1994)
7-O-Triflates of baccatin III or of taxol analogs are convenient precursors in alternate syntheses of Δ6,7-taxols and 7β,8β-methano (cyclopropyl) taxols, two of the products initially obtained from reaction of taxols with methylDAST; hydrazine
A semi-synthetic taxane derivative and its preparation method and application
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, (2019/03/10)
The invention discloses a semi-synthetic taxane derivative. An anti-tumor effect test shows that the semi-synthetic taxane derivative has relatively good anti-tumor activity on a human lung adenocarcinoma cell line A549, a human breast cancer cell line MCF-7, a human glioblastoma cell line U251, a human pancreatic cancer cell line PANC-1, a human colon cancer cell line HCT116 and a human non-small lung cancer cell line H460. The semi-synthetic taxane derivative can be used for preparing anti-tumor drugs.
PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST
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, (2012/06/18)
The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a β-lactam (C) in the presence of one or more Lewis acids and a base agent. The present invention also relates to a process of preparing the protected baccatin derivative (B) from a baccatin derivative (A) comprising a protection reaction catalyzed by one or more Lewis acids with an optional base agent.
