1588773-25-4

Basic information

• Product Name: 1-methyl-2-(p-tolyl)-3H-pyrrolo[1,2-a]indol-3-one
• Synonyms: 1-methyl-2-(p-tolyl)-3H-pyrrolo[1,2-a]indol-3-one
• CAS NO: 1588773-25-4
• Molecular Weight: 273.334
• Mol File: 1588773-25-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-(p-tolyl)-3H-pyrrolo[1,2-a]indol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(p-tolyl)-3H-pyrrolo[1,2-a]indol-3-one(1588773-25-4)
• EPA Substance Registry System: 1-methyl-2-(p-tolyl)-3H-pyrrolo[1,2-a]indol-3-one(1588773-25-4)

Safety Data

• Hazardous Substances Data: 1588773-25-4(Hazardous Substances Data)

Upstream product

• 2749-93-1 1-methyl-4-(1-propyn-1-yl)benzene 
• 1353752-27-8 (1H-indol-1-yl)(morpholin-4-yl)methanone 

Relevant articles and documents

Pyrroloindolone synthesis via a Cp*CoIII-catalyzed redox-neutral directed C-H alkenylation/annulation sequence

A unique synthetic utility of a Cp*CoIII catalyst in comparison with related Cp*RhIII catalysts is described. A C2-selective indole alkenylation/annulation sequence proceeded smoothly with catalytic amount of a [Cp*CoIII(C6H 6)](PF6)2 complex and KOAc. Intramolecular addition of an alkenyl-Cp*Co species to a carbamoyl moiety gave pyrroloindolones in 58-89% yield in one pot. Clear difference was observed between the catalytic activity of the Cp*CoIII complex and those of Cp*RhIII complexes, highlighting the unique nucleophilic activity of the organocobalt species. The Cp*CoIII catalysis was also suitable for simple alkenylation process of N-carbamoyl indoles, and broad range of alkynes, including terminal alkynes, were applicable to give C2-alkenylated indoles in 50-99% yield. Mechanistic studies on C-H activation step under Cp*CoIII catalysis with the aid of an acetate unit as well as evaluation of the difference between organo-Co III species and organo-RhIII species are also described.