158954-92-8

Basic information

• Product Name: Phosphonic acid, (1-hydroxy-3-phenylpropyl)-, bis(1-methylethyl) ester
• CAS NO: 158954-92-8
• Molecular Formula: C15H25O4P
• Molecular Weight: 300.335
• Mol File: 158954-92-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (1-hydroxy-3-phenylpropyl)-, bis(1-methylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (1-hydroxy-3-phenylpropyl)-, bis(1-methylethyl) ester(158954-92-8)
• EPA Substance Registry System: Phosphonic acid, (1-hydroxy-3-phenylpropyl)-, bis(1-methylethyl) ester(158954-92-8)

Safety Data

• Hazardous Substances Data: 158954-92-8(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 1809-20-7 diisopropyl hydrogenphosphonate 

Downstream Products

• 189386-98-9 (+/-)-diisopropyl 1-chloroacetoxy-3-phenylpropylphosphonate 

Relevant articles and documents

Determination of Absolute Configuration of α-Hydroxyphosphonates by 31P NMR Spectroscopy of Corresponding Mosher Esters

(R)-MTPA esters of α-hydroxyphosphonates 1a-h of known absolute configuration were prepared and their 31P NMR spectra were recorded.The chemical shifts of the 31P signals of the derivatized (S)-alcohols are consistently downfield relative to the signals of the corresponding (R)-alcohols.A variety of racemic and diastereomeric α-hydroxyphosphonates 1i-o and their (R)-MTPA esters were prepared.The 31P chemical shift differences are large enough to securely assign absolute configurations to α-hydroxyphosphonates.

Enzymes in organic chemistry - 5: First and chemo-enzymatic synthesis of α-aminooxyphosphonic acids of high enantiomeric excess

α-Acyloxyphosphonates (±)-5a and (±)-5b, derived from 3-phenylpropionaldehyde and acetaldehyde, were resolved by lipase-catalyzed enantioselective hydrolysis. Three of the four chiral, non-racemic α-hydroxyphosphonates obtained had 99% ee, the fourth 91%.