1590346-29-4

Basic information

• Product Name: 2,2,2-trifluoroethyl 2-hydroxy-5-methoxybenzoate
• Synonyms: 2,2,2-trifluoroethyl 2-hydroxy-5-methoxybenzoate
• CAS NO: 1590346-29-4
• Molecular Weight: 250.174
• Mol File: 1590346-29-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoroethyl 2-hydroxy-5-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoroethyl 2-hydroxy-5-methoxybenzoate(1590346-29-4)
• EPA Substance Registry System: 2,2,2-trifluoroethyl 2-hydroxy-5-methoxybenzoate(1590346-29-4)

Safety Data

• Hazardous Substances Data: 1590346-29-4(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 2612-02-4 5-methoxysalicylic acid 
• 150-76-5 4-methoxy-phenol 
• 78646-39-6 2-(4-methoxyphenoxy)pyridine 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

An efficient approach for the synthesis of 1,2-dihydroxanthones enabled by one-pot Claisen condensation/cyclization reactions

1,2-Dihydroxanthones (DHXs) are core structures of natural products and useful building blocks in organic synthesis. So far, they have been less studied. In this report, a mild, efficient and green method for the synthesis of 1,2-dihydroxanthones has been developed in one pot through Claisen condensation and O-cyclization under waste-induced relay catalysis with minimum organic solvents. The by-product (HMDS or NH3·H2O) of the first step turned out to be the promoter for the second step, which could efficiently proceed in aqueous media without the addition of other catalysts. The reactions using trifluoroethyl salicylates could be performed under mild conditions to ensure the generation of vulnerable DHXs in high yields. The substrate scope is very broad regardless of the substituent type and its position on the structure. Specifically, the versatility of DHXs was demonstrated by their conversion to xanthones and other complex structures.