1590361-85-5 Usage
Description
(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-imidazol-1-yl)methanone is a pharmaceutical intermediate belonging to the class of imidazole-based compounds. It is a white to off-white powder with a molecular formula of C17H17F2N3O3 and a molecular weight of 355.33 g/mol.
Used in Pharmaceutical Industry:
(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)(1H-imidazol-1-yl)methanone is used as a pharmaceutical intermediate for the synthesis and development of potential medications for various medical conditions. It exhibits biological activity as a potent inhibitor of certain enzymes or receptors, making it a valuable tool for medicinal chemistry research and drug discovery.
Further studies are being conducted to explore its potential therapeutic applications in the treatment of specific diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1590361-85-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,0,3,6 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1590361-85:
(9*1)+(8*5)+(7*9)+(6*0)+(5*3)+(4*6)+(3*1)+(2*8)+(1*5)=175
175 % 10 = 5
So 1590361-85-5 is a valid CAS Registry Number.
1590361-85-5Relevant articles and documents
PROCESS FOR PREPARING ROFLUMILAST
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, (2014/05/07)
The invention relates to a process for the preparation of Roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid with an activating agent selected from (a) carbonyldiimidazole (CDI), (b) 1,1'-carbonyl-di-(1,2,4-triazol) (CDT), (c) 1,1'-carbonyl-bis-(2-methylimidazol), (d),1'-carbonyl-dipyperidin, (e) N,N'-dicyclohexylcarbodiimide (DCC), (f) N,N′-diisopropylcarbodiimide (DIC), (g) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and a combination of one of the previous (a)-(g) with (h) N-hydroxysuccinimide or (i) N-hydroxyphthalimide, and the subsequent reaction with 3,5-dichloropyridine-4-amine in the presence of an inorganic base. The invention also relates to the synthesis intermediates.
