15909-83-8

Basic information

• Product Name: 3-HYDROXYPROPANESULFONIC ACID
• Synonyms: 3-hydroxy-1-propanesulfonicaci;3-hydroxy-1-Propanesulfonicacid;Hydroxypropanesulfonicacid;3-HYDROXYPROPANE-1-SULFONIC ACID;3-HYDROXYPROPANESULFONIC ACID;HPSA;3-hydroxypropanesulphonic acid;3-hydroxypropan-sulfonsure
• CAS NO: 15909-83-8
• Molecular Formula: C₃H₈O₄S
• Molecular Weight: 140.16
• EINECS: 240-051-8
• Product Categories: Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds
• Mol File: 15909-83-8.mol
• Article Data: 9

Chemical Properties

• Flash Point: 100 °C
• Appearance: /
• Density: 1.364 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.456
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.69±0.50(Predicted)
• BRN: 1753832
• CAS DataBase Reference: 3-HYDROXYPROPANESULFONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXYPROPANESULFONIC ACID(15909-83-8)
• EPA Substance Registry System: 3-HYDROXYPROPANESULFONIC ACID(15909-83-8)

Safety Data

• Hazard Codes: T
• Statements: 45-21/22-35
• Safety Statements: 53-26-36/37/39-45
• RIDADR: UN 3265 8/PG 1
• WGK Germany: 1
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 15909-83-8(Hazardous Substances Data)

Usage

Description

3-HYDROXYPROPANESULFONIC ACID, also known as 3-Hydroxy-1-propanesulfonic acid, is an organic compound with the molecular formula C3H9O4S. It is a colorless liquid that may contain up to ~40% (NMR) 3,3′-Oxydi(propanesulfonic acid). 3-HYDROXYPROPANESULFONIC ACID is characterized by its hydroxy and sulfonic acid functional groups, which provide it with unique chemical properties and make it suitable for various applications.

Uses

Used in Chemical Synthesis:
3-HYDROXYPROPANESULFONIC ACID is used as a key intermediate in the preparation of Propane Sultone from Hydroxypropanesulfonic Acid. This synthesis is important for the production of various chemical compounds and materials that have applications in different industries.
Used in Pharmaceutical Industry:
3-HYDROXYPROPANESULFONIC ACID can be used as a buffering agent in the development of pharmaceutical formulations. Its ability to maintain a stable pH environment makes it suitable for stabilizing sensitive biological molecules and ensuring the efficacy of drug formulations.
Used in Environmental Applications:
3-HYDROXYPROPANESULFONIC ACID can be employed in the treatment of wastewater and other environmental applications. Its acidic properties allow it to act as a chelating agent, helping to remove heavy metals and other contaminants from water sources.
Used in Research and Development:
3-HYDROXYPROPANESULFONIC ACID is also used as a research compound in various scientific studies. Its unique chemical properties make it a valuable tool for understanding the behavior of different chemical systems and developing new materials and applications.

InChI:InChI=1/C3H8O4S/c4-2-1-3-8(5,6)7/h4H,1-3H2,(H,5,6,7)

Upstream product

• 627-18-9 1-bromo-3-propanol 
• 30453-21-5 3-[(3-hydroxypropyl)disulfanyl]-1-propanol 
• 627-30-5 1-chloro-3-hydroxypropane 
• 2495-39-8 sodium prop-2-ene-1-sulfonate 
• 3542-44-7 sodium 3-hydroxypropanesulphonate 
• 14533-63-2 1-propanesulfonic acid sodium salt 
• 107-18-6 allyl alcohol 
• 108214-47-7 N-nitrosopropanesultam 
• 1120-71-4 1,3-propanesultone 
• 107-02-8 acrolein 
• 71-23-8 propan-1-ol 

Downstream Products

• 1633-82-5 3-chloro-n-propanesulfonyl chloride 
• 637031-10-8 3-benzyloxypropane-1-sulfonic acid sodium salt 
• 946566-58-1 C₁₁H₁₅NO₅S 
• 50437-50-8 3-phenylpropane-1-sulfonic acid 
• 62607-64-1 4-phenyl-butane-1-sulfonic acid 
• 1120-71-4 1,3-propanesultone 
• 79749-62-5 3-Hydroxy propane sulfonic acid-(3-sulfopropyl)-ester 

Relevant articles and documents

Kinetics of the Aqueous Periodate Oxidation of Aliphatic Disulfides and Thioethers

Water-soluble aliphatic disulfides are oxidatively cleaved by borate-buffered periodate at 23 deg C.The reaction conditions were selected because they are used for the oxidation of methionine in protein modification, and we wanted to test the reactivity of the disulfide linkage in various bifunctional molecules under these conditions.A colorimetric method was developed which uses 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) to determine the concentrations of periodate.The γ-substituted amine-disulfide 1b consumes 4 equiv of periodate at a rate which is accelerated 100-fold over that of 4,4'-dithiodibutanol (1c) and forms the cyclic sulfinamide 3 an sulfonamide 4.To account for the stoichiometry and acceleration, we have proposed intermediates in which a nucleophilic sulfur atom attacks an oxygen atom of periodate to give an anhydride or complex rather than invoking direct oxygen atom transfer.The γ- and δ-hydroxy disulfides 1a and 1c consume 5 equiv of periodate and are oxidized to the sulfonic acids.The rate of DL-methionine (2a) oxidation in water is reported, along with the oxidations of dibutyl sulfide (2c) and of 1,5-dithiacyclooctane (2d) in 50percent aqueous ethanol.The oxidation of 2d is only 2.1 times faster than the oxidation of 2c, showing that the transannular sulfur atom in 2d does not participate in the oxidation.A comparison of the rate of periodate oxidation of disulfides, thioethers, and ethylene glycol under the same conditions shows that it is possible for these processes to be competitive.

1,3-propane sultone preparation method

The invention relates to a 1,3-propane sultone preparation method, which comprises: S1, completely mixing in a reaction container by using 3-chloropropanol and sodium sulfite as raw materials and using water as a solvent, controlling the temperature at 25-120 DEG C, carrying out a reaction for 4-48 h, carrying out pressure reducing dewatering concentration, adding concentrated hydrochloric acid tothe concentrated liquid, carrying out acidification, controlling the temperature at 0-80 DEG C, stirring for 1-24 h, filtering, and concentrating the filtrate to obtain 3-hydroxypropanesulfonic acid;S2, controlling the temperature of the concentrated liquid obtained in the step S1 at 40-110 DEG C, and carrying out pressure reducing concentrating to carry out dewatering ring closure on the 3-hydroxypropanesulfonic acid in the concentrated liquid to obtain a crude product containing 1,3-propane sultone; and S3, rectifying the crude product containing 1,3-propane sultone to obtain 1,3-propane sultone. According to the present invention, the method has characteristics of short process route, less three-waste and simple post-treatment, wherein the total yield can achieve more than 90%, and the purity of the product can achieve more than 99.9%.

Method for preparing 1,3-propane sultone

The invention discloses a method for preparing 1,3-propane sultone. The method includes the steps that (1) 1,3-propanesulfonic acid is prepared: sodium sulfite, sodium bisulfite and allyl alcohol are added into a reactor under the room temperature condition, a pH value is regulated to be 5 to 5.5, infrared radiation induction is adopted, azo diisobutyl nitrile performs catalytic reaction for 2 to 3 hours, concentrated hydrochloric acid is added, the reaction is performed at the temperature of 85 to 90 DEG C for 2 to 3 hours, generated salt is removed through filtration, and n-butyl alcohol is added into filtrate to perform extraction separation so as to obtain the 3-hydroxy-1-propanesulfonic acid; (2) the 1,3-propane sultone is prepared: pyridinium p-toluenesulfonate and zeolites are added, dehydration reaction is performed at the temperature of 50-60 DEG C for 2-3 hours, distillation is performed to obtain 147-149 DEG C of fraction, and calcium oxide is added to perform heating reflux for 1-2 hours to obtain the 1,3-propane sultone. The product prepared by means of the method is high in yield and purity. In addition, the moisture content of the product is mostly above 0.1%, the amplification effect and other problems do not exist, and the method is suitable for industrial production.