159177-91-0 Usage
Description
1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE, with the molecular formula C11H11F3NO, is a chemical compound belonging to the class of piperidine derivatives. It features a phenyl group with a trifluoromethyl substitution at the 3-position, which contributes to its lipophilic nature. 1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE is of interest in the fields of organic synthesis and medicinal chemistry, particularly for the development of novel pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Development:
1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE is used as a key intermediate in the synthesis of new pharmaceuticals. Its unique structure and properties make it a promising candidate for the development of drugs targeting various medical conditions.
Used in Agrochemical Development:
In the agrochemical industry, 1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE is utilized as a building block for the creation of new compounds with potential applications in pest control and crop protection.
Used in Central Nervous System Depressant Research:
1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE is studied for its potential as a central nervous system depressant, which could be useful in the development of medications for anxiety, insomnia, and other related conditions.
Used in Analgesic Drug Development:
1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE is also being investigated for its analgesic properties, which could lead to the development of new pain-relieving medications.
Used in Dopamine Receptor Antagonist Research:
1-(3-TRIFLUOROMETHYL-PHENYL)-PIPERIDIN-2-ONE has shown activity as a dopamine receptor antagonist, making it a candidate for the development of drugs targeting neurological and psychiatric disorders, such as Parkinson's disease and schizophrenia.
The trifluoromethyl group in the compound may influence its pharmacokinetic properties and bioavailability, which is a factor that researchers consider when studying its potential applications. Further research is necessary to fully understand the uses and effects of 1-(3-trifluoromethyl-phenyl)-piperidin-2-one.
Check Digit Verification of cas no
The CAS Registry Mumber 159177-91-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,1,7 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 159177-91:
(8*1)+(7*5)+(6*9)+(5*1)+(4*7)+(3*7)+(2*9)+(1*1)=170
170 % 10 = 0
So 159177-91-0 is a valid CAS Registry Number.
159177-91-0Relevant articles and documents
Copper/N,N-dimethylglycine catalyzed Goldberg reactions between aryl bromides and amides, aryl iodides and secondary acyclic amides
Jiang, Liqin
supporting information, p. 13448 - 13460 (2015/02/19)
An efficient and general copper-catalyzed Goldberg reaction at 90-110 °C between aryl bromides and amides providing the desired products in good to excellent yields has been developed using N,N-dimethylglycine as the ligand. The reaction is tolerant toward a wide range of amides and a variety of functional group substituted aryl bromides. In addition, hindered, unreactive aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, are efficiently coupled with aryl iodides through this simple and cheap copper/N,N-dimethylglycine catalytic system.
Herbicidally active phenylsubstituted 5-and 6-membered heterocyclic compounds
-
, (2008/06/13)
A compound of formula (I): STR1 where E is oxygen or sulphur; A is CR3 or N where R3 is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxygen, nitrogen or sulphur and which is optionally substituted by an optionally substituted lower hydrocarbyl group, or an optionally substituted heteroaryl group; R1 and R2 are each independently hydrogen; optionally substituted lower hydrocarbyl, or optionally substituted heteroaryl, or R1 and R2 together with the nitrogen atom to which they are attached, form a heterocyclic ring; Z represents halogen optionally substituted lower hydrocarbyl, optionally substituted lower hydocarbyloxy, optionally substituted lower hydrocarbylthio, hydrocarbylsulphinyl or hydrocarbylsulphonyl, cyano, nitro, CHO, NHOH, ONR7' R7", SF5 ; CO (optionally substituted lower hydrocarbyl), acylamino, COOR7, SO2 NR8 R9, CONR10 R11, OR12 or NR13 R14 where R7, R7', R7", R8, R9, R10 and R11 are independently hydrogen or lower hydrocarbyl; R12 is hydrogen; SO2 lower hydrocarbyl or COR15 ; R13 and R14 are independently lower hydrocarbyl, lower hydrocarbyloxy or a group R12 ; R15 is OR16, NR17 R18, hydrogen or lower hydrocarbyl; R16 is lower hydrocarbyl; R17 and R18 are independently hydrogen or lower hydrocarbyl; provided that when there are two or more substituents Z, they may be the same or different; and m is 0 or an integer from 1 to 5.
