159326-69-9

Basic information

• Product Name: 1H-Pyrrole-2-carboxamide,1-amino-(9CI)
• Synonyms: 1H-Pyrrole-2-carboxamide,1-amino-(9CI);1-AMINO-1H-PYRROLE-2-CARBOXAMIDE;1-AMino-1H-pyrrole-2-carboxylic acid aMide;1H-Pyrrole-2-carboxamide, 1-amino-;1-aminopyrrole-2-carboxamide
• CAS NO: 159326-69-9
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.13
• Product Categories: AMINEPRIMARY;PYRROLE
• Mol File: 159326-69-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 425.897 °C at 760 mmHg
• Flash Point: 211.375 °C
• Appearance: /
• Density: 1.457 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: 2-8°C(protect from light)
• PKA: 16.23±0.50(Predicted)
• CAS DataBase Reference: 1H-Pyrrole-2-carboxamide,1-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxamide,1-amino-(9CI)(159326-69-9)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxamide,1-amino-(9CI)(159326-69-9)

Safety Data

• Hazardous Substances Data: 159326-69-9(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-2-carboxamide, 1-amino-(9CI) is a chemical compound with the molecular formula C5H6N2O. It is an amide derivative of pyrrole, a five-membered aromatic heterocyclic compound. 1H-Pyrrole-2-carboxamide,1-amino-(9CI) is also known as 2-pyrrolecarboxamide and has an amine group attached to the carbon at the 1-position of the pyrrole ring. It has various applications in organic synthesis and pharmaceutical research, including as a building block for the synthesis of other organic compounds and potential drug molecules. Additionally, its unique structure and properties make it a valuable tool for the study of the reactivity and behavior of heterocyclic compounds in chemical reactions.

InChI:InChI=1/C5H7N3O/c6-5(9)4-2-1-3-8(4)7/h1-3H,7H2,(H2,6,9)

Upstream product

• 159326-70-2 1-formylaminopyrrole-2-carboxamide 
• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 1003-29-8 2-pyrrole aldehyde 
• 159326-66-6 N-amino-1H-pyrrole-2-carbonitrile 

Downstream Products

• 159326-70-2 1-formylaminopyrrole-2-carboxamide 
• 1561810-91-0 4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-N-(2-methyl-5-(pyrrolidin-1-ylmethyl)phenyl)benzamide 
• 1561810-85-2 4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-N-(2-methyl-5-(piperidin-1-ylmethyl)phenyl)benzamide 
• 1561810-80-7 4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide 
• 1561810-77-2 N-(2-methyl-5-(4-morpholinyl)methylphenyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-ylamino)benzamide 
• 1561810-43-2 N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 
• 1561810-41-0 N-(5-(hydroxymethyl)-2-methylphenyl)-4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 
• 1561810-37-4 4-((4-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzoic acid 
• 1561810-74-9 N-(2-methyl-5-(pyrrolidin-1-ylmethyl)phenyl)-4-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 
• 1561810-71-6 N-(2-methyl-5-(piperidin-1-ylmethyl)phenyl)-4-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 
• 1561810-68-1 N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 
• 1561810-65-8 N-{2-methyl-5-((morpholin-4-yl)methyl)phenyl}-4-(4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-ylamino)benzamide 
• 1561810-30-7 N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 
• 1561810-26-1 N-(5-(hydroxymethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide 

Relevant articles and documents

Substituted heteroaryl compounds and compositions and uses thereof

The invention provides a substituted heteroaryl compound and a composition thereof, and applications of the compound and the composition. The compound is a compound as shown in a formula I, or stereoisomer, tautomer, oxynitride, solvate, metabolite, pharmaceutically-acceptable salt or prodrug of the compound as shown in the formula I. The invention also provides a pharmaceutical composition containing the above-mentioned compound; and the above-mentioned compound and the pharmaceutical composition are capable of adjusting the activity of JAK kinases and are applied in prevention, treatment, therapy and alleviation of JAK kinase mediated diseases or disorders.

Synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound

The invention discloses a synthesis and medical application of pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound. The compound belongs to a novel-structure compound. The synthesis method is high in operating safety, mild in reaction condition and suitable for industrial production. The activity and the selectivity of BTK kinase and the in-vitro proliferation activity of a leukemia cell line are test, it is verified that the compound has the selective and irreversible inhibition effect on the BTK kinase, and has the different-degree inhibition effect on leukemia cells. According to measurement, the compound also has the good anti-arthritic activity on a collagen-induced arthritis (rCIA) model. The pyrrolo-[2,1-f] [1,2,4] triazine mother nucleus compound can be used for preparing medicine for treating arthritis and leukemia.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a JAK-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated disease.