159487-43-1

Basic information

• Product Name: Isopropyl (2S)-N-(trifluoroacetyl)-phosphohomoserine dibenzyl ester
• CAS NO: 159487-43-1
• Molecular Weight: 517.439
• Mol File: 159487-43-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Isopropyl (2S)-N-(trifluoroacetyl)-phosphohomoserine dibenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropyl (2S)-N-(trifluoroacetyl)-phosphohomoserine dibenzyl ester(159487-43-1)
• EPA Substance Registry System: Isopropyl (2S)-N-(trifluoroacetyl)-phosphohomoserine dibenzyl ester(159487-43-1)

Safety Data

• Hazardous Substances Data: 159487-43-1(Hazardous Substances Data)

Upstream product

• 108549-23-1 Dibenzyl N,N-diisopropylphosphoramidite 
• 57744-84-0 1-Isopropyl (2S)-N-(trifluoroacetyl)aspartate 
• 159487-41-9 Isopropyl (2S)-N-(trifluoroacetyl)homoserine 
• 777-33-3 N-trifluoroacetyl-L-aspartic acid anhydride 

Relevant articles and documents

Synthesis of (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers: Probes for the pyridoxal phosphate-dependent threonine synthase reaction

A short efficient synthesis of the threonine synthase substrate (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers is described. The synthetic route also provides access to (2S)-homoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers in high yield. Preliminary deuterium isotope effect determinations performed using the deuteriated (2S)-O-phosphohomoserines and threonine synthase from E. coli indicate that the removal of protons from both C-2 and C-3 is kinetically important.