159490-55-8 Usage
Description
Ketoprofen-D3 is a deuterated analog of the nonsteroidal anti-inflammatory drug (NSAID) Ketoprofen. It is commonly used as an internal standard in analytical chemistry for the quantification of Ketoprofen by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry. The presence of deuterium (D3) in its molecular structure allows for differentiation between the analyte and the internal standard, ensuring accurate and reliable quantification.
Uses
Used in Pharmaceutical Industry:
Ketoprofen-D3 is used as an internal standard for the quantification of Ketoprofen in pharmaceutical applications. It aids in the accurate measurement of Ketoprofen levels in various formulations, ensuring the quality and efficacy of the drug.
Used in Research and Development:
In the field of research and development, Ketoprofen-D3 serves as an essential tool for the analysis of Ketoprofen in biological samples. It helps researchers to study the pharmacokinetics, pharmacodynamics, and metabolism of Ketoprofen, contributing to the development of new drugs and therapies.
Used in Quality Control:
Ketoprofen-D3 is utilized in quality control processes to ensure the consistency and potency of Ketoprofen-containing products. By using Ketoprofen-D3 as an internal standard, laboratories can accurately determine the concentration of Ketoprofen in samples, ensuring that the products meet the required standards and specifications.
Used in Toxicology and Forensic Analysis:
In toxicology and forensic analysis, Ketoprofen-D3 is employed as an internal standard for the detection and quantification of Ketoprofen in various biological samples, such as blood, urine, and tissue. This helps in the investigation of drug overdoses, drug-facilitated crimes, and other related cases.
Check Digit Verification of cas no
The CAS Registry Mumber 159490-55-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,4,9 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 159490-55:
(8*1)+(7*5)+(6*9)+(5*4)+(4*9)+(3*0)+(2*5)+(1*5)=168
168 % 10 = 8
So 159490-55-8 is a valid CAS Registry Number.
159490-55-8Relevant articles and documents
The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake
Venteicher, Brooklynn,Merklin, Kasey,Ngo, Huy X.,Chien, Huan-Chieh,Hutchinson, Keino,Campbell, Jerome,Way, Hannah,Griffith, Joseph,Alvarado, Cesar,Chandra, Surabhi,Hill, Evan,Schlessinger, Avner,Thomas, Allen A.
supporting information, p. 869 - 880 (2020/12/15)
The l-type amino acid transporter 1 (LAT1, SLC7A5) imports dietary amino acids and amino acid drugs (e. g., l-DOPA) into the brain, and plays a role in cancer metabolism. Though there have been numerous reports of LAT1-targeted amino acid-drug conjugates (prodrugs), identifying the structural determinants to enhance substrate activity has been challenging. In this work, we investigated the position and orientation of a carbonyl group in linking hydrophobic moieties including the anti-inflammatory drug ketoprofen to l-tyrosine and l-phenylalanine. We found that esters of meta-carboxyl l-phenylalanine had better LAT1 transport rates than the corresponding acylated l-tyrosine analogues. However, as the size of the hydrophobic moiety increased, we observed a decrease in LAT1 transport rate with a concomitant increase in potency of inhibition. Our results have important implications for designing amino acid prodrugs that target LAT1 at the blood-brain barrier or on cancer cells.