1596278-56-6

Basic information

• Product Name: (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate
• Synonyms: (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate
• CAS NO: 1596278-56-6
• Molecular Weight: 208.257
• Mol File: 1596278-56-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate(1596278-56-6)
• EPA Substance Registry System: (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate(1596278-56-6)

Safety Data

• Hazardous Substances Data: 1596278-56-6(Hazardous Substances Data)

Upstream product

• 61560-94-9 3-methylphenyloxoacetic acid 
• 66644-68-6 ethyl 2-oxo-2-(m-tolyl)acetate 
• 17933-03-8 m-tolylboronic acid 
• 924-53-8 isopropyl glyoxalate 

Relevant articles and documents

Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters

A rhodium-catalyzed enantioselective addition of glyoxylates to arylboronic acids promoted by a simple chiral sulfinamide-based olefin ligand under mild reaction conditions is described. The reaction provides access to a variety of optically active substituted mandelic acid esters in good yields with up to 83percent ee. The catalytic system is also applicable to pyruvate addition. The synthetic utility of this method is highlighted by a formal synthesis of the antiplatelet drug clopidogrel.

Enantio- and chemoselective Br?nsted-acid/Mg(nBu) 2 catalysed reduction of α-keto esters with catecholborane

The first enantio- and chemoselective Br?nsted-acid catalysed reduction of α-keto esters with catecholborane has been developed. The α-hydroxy esters were obtained under mild reaction conditions in virtually quantitative yields and excellent enantioselectivities. With slight modifications both enantiomers can be obtained without any loss of selectivity. This journal is the Partner Organisations 2014.