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159783-41-2

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159783-41-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 159783-41-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,7,8 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 159783-41:
(8*1)+(7*5)+(6*9)+(5*7)+(4*8)+(3*3)+(2*4)+(1*1)=182
182 % 10 = 2
So 159783-41-2 is a valid CAS Registry Number.

159783-41-2Relevant articles and documents

Synthesis and biological evaluation of cystobactamid 507: A bacterial topoisomerase inhibitor from Cystobacter sp.

Moreno, María,Elgaher, Walid A.M.,Herrmann, Jennifer,Schl?ger, Nadin,Hamed, Mostafa M.,Baumann, Sascha,Müller, Rolf,Hartmann, Rolf W.,Kirschning, Andreas

, p. 1175 - 1178 (2015)

Abstract The first total synthesis of cystobactamid 507, a member of a class of new natural products with strong inhibitory activity towards bacterial topoisomerases, is reported. Synthetic key challenges are the central tetrasubstitued arene and the low chemical reactivity of anilines and ortho-phenolic and isopropoxy-substituted benzoic acids. Biological evaluations demonstrate that cystobactamid 507 inhibits several Gram-positive pathogens but at significantly lower concentrations than described for the larger members of this natural product family.

A structure—activity relationship study of bis-benzamides as inhibitors of androgen receptor—coactivator interaction

Lee, Tae-Kyung,Ravindranathan, Preethi,Sonavane, Rajni,Raj, Ganesh V.,Ahn, Jung-Mo

supporting information, (2019/08/07)

The interaction between androgen receptor (AR) and coactivator proteins plays a critical role in AR-mediated prostate cancer (PCa) cell growth, thus its inhibition is emerging as a promising strategy for PCa treatment. To develop potent inhibitors of the

NOVEL CYSTOBACTAMIDE DERIVATIVES

-

Page/Page column 61-62, (2019/03/12)

The present invention relates to novel derivatives of cystobactamides of formula (lb) and the use thereof for the treatment or prophylaxis of bacterial infections.

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