159803-05-1

Basic information

• Product Name: diethyl 2-(2,3-diphenylquinoxalin-6-ylaminomethylene)malonate
• Synonyms: diethyl 2-(2,3-diphenylquinoxalin-6-ylaminomethylene)malonate
• CAS NO: 159803-05-1
• Molecular Weight: 467.524
• Mol File: 159803-05-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl 2-(2,3-diphenylquinoxalin-6-ylaminomethylene)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-(2,3-diphenylquinoxalin-6-ylaminomethylene)malonate(159803-05-1)
• EPA Substance Registry System: diethyl 2-(2,3-diphenylquinoxalin-6-ylaminomethylene)malonate(159803-05-1)

Safety Data

• Hazardous Substances Data: 159803-05-1(Hazardous Substances Data)

Upstream product

• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 134-81-6 benzil 
• 7466-46-8 2,3-diphenyl-6-amino-quinoxaline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1600514-62-2 7-(4-(trifluoromethyl)benzyl)-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylic acid 
• 1600514-61-1 7-(4-fluorobenzyl)-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylic acid 
• 1600514-60-0 10-oxo-2,3-diphenyl-7-(prop-2-ynyl)-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylic acid 
• 1600514-59-7 7-butyl-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylic acid 
• 1600514-58-6 10-oxo-2,3-diphenyl-7-(2,2,2-trifluoroethyl)-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylic acid 
• 1600514-57-5 7-ethyl-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylic acid 
• 1600514-50-8 ethyl 7-(4-(trifluoromethyl)benzyl)-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylate 
• 1600514-49-5 ethyl 7-(4-fluorobenzyl)-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylate 
• 1600514-48-4 ethyl 10-oxo-2,3-diphenyl-7-(prop-2-ynyl)-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylate 
• 1600514-47-3 ethyl 7-butyl-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylate 
• 1600514-46-2 ethyl 10-oxo-2,3-diphenyl-7-(2,2,2-trifluoroethyl)-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylate 
• 1600514-45-1 ethyl 7-ethyl-10-oxo-2,3-diphenyl-7,10-dihydropyrido[3,2-f]quinoxaline-9-carboxylate 
• 174623-03-1 5,8-Dihydro-2,3-diphenyl-7-ethoxycarbonyl-8-oxopyrido<3,2-f>quinoxaline 
• 174623-03-1 10-Hydroxy-2,3-diphenyl-pyrido[3,2-f]quinoxaline-9-carboxylic acid ethyl ester 

Relevant articles and documents

Gould-Jacobs Reaction of 6-Amino-2,3-diphenylquinoxaline

Catalytic hydrogenation of 2,3-diphenyl-6-nitroquinoxaline led to the corresponding amine 1 which in turn afforded products 3a-i on reaction with alkoxymethylene derivatives 2a-i.Thermal cyclization of 3b and 3f yielded substituted pyrazinoquinolones 5b a

Synthesis and antimalarial activity of pyridoquinoxalines and their N-oxides

Unsubstituted, 2,3-dimethyl, and 2,3-diphenyl 10-chloro pyridoquinoxalines have been prepared and converted to 10-substituted amino and Mannich base derivatives.Pyridoquinoxaline undergoes oxidation in the presence of m-CPBA to give the corresponding mono and bis N-oxides.The mono N-oxide reacts with POCl3 to give the dichloro derivative and with trimethyl silyl cyanide to give the 8-cyano-10-chloro derivative.The dichloro pyridoquinoxaline further undergoes oxidation with m-CPBA to give dichloro mono N-oxide.All the compounds have beeen testedin the Plasmodium berghei infected mice by oral route.Compounds 9, and 12 displayed 100percent activity in K-173 infected mice at 25 mg/kg.