159818-67-4Relevant articles and documents
A Non-Peptide NK1 Receptor Agonist Showing Subpicomolar Affinity
Cappelli, Andrea,Giuliani, Germano,Mohr, Galla Pericot,Gallelli, Andrea,Anzini, Maurizio,Vomero, Salvatore,Cupello, Aroldo,Scarrone, Simona,Matarrese, Mario,Moresco, Rosa Maria,Fazio, Ferruccio,Finetti, Federica,Morbidelli, Lucia,Ziche, Marina
, p. 1315 - 1318 (2007/10/03)
3-Quinolinecarboxamides have been synthesized and evaluated for their binding to the human NK1 receptor. Several secondary amide derivatives show NK1 receptor affinity in the picomolar range. The most active compound, hydroxymethylca