159846-14-7

Basic information

• Product Name: L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)diphenylsilyl]-, methyl ester
• CAS NO: 159846-14-7
• Molecular Formula: C25H35NO5Si
• Molecular Weight: 457.642
• Mol File: 159846-14-7.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)diphenylsilyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)diphenylsilyl]-, methyl ester(159846-14-7)
• EPA Substance Registry System: L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)diphenylsilyl]-, methyl ester(159846-14-7)

Safety Data

• Hazardous Substances Data: 159846-14-7(Hazardous Substances Data)

Upstream product

• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 159846-17-0 [(R)-1-[(E)-Benzylimino-methyl]-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester 
• 154456-41-4 [(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-formyl-ethyl]-carbamic acid tert-butyl ester 
• 198417-69-5 tert-butyl [(1R)-2-(tert-butyldiphenylsilyloxy)-1-(hydroxymethyl)-ethyl]carbamate 
• 651031-09-3 (2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy-(4S)-methyl-2,2-dimethyl-[1,3]-dioxolane 
• 651031-10-6 3-[(2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy]-(2R)-propane-1,2-diol 
• 651031-11-7 3-[(2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy]-(2S)-1-(tert-butyldiphenylsilyloxy)propan-2-ol 
• 651031-12-8 3-[(2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy]-(2S)-1-(tert-butyldiphenylsilyloxy)-2-(methanesulfonyl)propane 
• 260391-22-8 (2S)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propyl methanesulfonate 
• 260391-24-0 (3R)-amino-4-(tert-butyldiphenylsilyloxy)butyronitrile 
• 260391-23-9 tert-butyl [(R)-1-cyanomethyl-2-(tert-butyldiphenylsilyloxy)ethyl]carbamate 
• 260391-28-4 (3R,3aS,7aR)-4-(tert-butyldiphenylsilyloxy)-3-(1-oxooctahydroisoindol-2-yl)butyronitrile 
• 260391-27-3 (3R,3aR,7aS)-4-(tert-butyldiphenylsilyloxy)-3-(1-oxooctahydroisoindol-2-yl)butyronitrile 

Relevant articles and documents

New Spisulosine Derivative promotes robust autophagic response to cancer cells

Therapy resistance by evasion of apoptosis is one of the hallmarks of human cancer. Therefore, restoration of cell death by non-apoptotic mechanisms is critical to successfully overcome therapy resistance in cancer. By rational drug design approach, here we try to provide evidence that subtle changes in the chemical structure of spisulosine completely switched its cytotoxic function from apoptosis to autophagy. Our most potent molecule (26b) in a series of 16 synthesized derivatives showed robust autophagic cell death in diverse cancer cells sparing normal counterpart. Compound 26b mediated lethal autophagy induction was confirmed by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins. Altogether, we have detected novel autophagy inducer small molecule which can be tested further for drug discovery research.

CERAMIDE DERIVATIVE HAVING SMS2 INHIBITORY ACTIVITY

PROBLEM TO BE SOLVED: To provide a ceramide derivative having excellent SMS2 inhibitory activity, preferably, a ceramide derivative having high SMS2 selectivity. SOLUTION: The present invention provides a compound represented by formula (I) or a pharmaceu

A practical method for selective cleavage of a tert-butoxycarbamoyl N-protective group from N,N-diprotected α-amino acid derivatives using montmorillonite K-10

A new, practical, and mild procedure for the selective cleavage of a tert-butoxycarbonyl group (Boc) in N-Boc-N-acyl-diprotected amines is described. When applied to α-amino acids, complete integrity of the stereochemistry was observed. The use of N,N-di-Boc-α-amino-δ- and γ-hydroxy esters provided both δ- and γ-lactones in very good yields. The method is based on the use of Montmorillonite K-10 either in CH 2Cl2 at room temperature or in toluene at 65°C and is compatible with the presence of a large range of functional and other protecting groups in the substrates. In most cases virtually pure samples are obtained after filtration and removal of solvents. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.