159874-26-7

Basic information

• Product Name: 1,4''-BIPIPERIDIN-2-ONE
• Synonyms: 1,4''-BIPIPERIDIN-2-ONE;[1,4']BIPIPERIDINYL-2-ONE;[1,4']biperidinyl-2-one
• CAS NO: 159874-26-7
• Molecular Formula: C₁₀H₁₈N₂O
• Molecular Weight: 182.2627
• Mol File: 159874-26-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 58.3 °C
• Boiling Point: 335.272 °C at 760 mmHg
• Flash Point: 156.567 °C
• Appearance: /
• Density: 1.071 g/cm³
• PKA: 9.90±0.10(Predicted)
• CAS DataBase Reference: 1,4''-BIPIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4''-BIPIPERIDIN-2-ONE(159874-26-7)
• EPA Substance Registry System: 1,4''-BIPIPERIDIN-2-ONE(159874-26-7)

Safety Data

• Hazardous Substances Data: 159874-26-7(Hazardous Substances Data)

Usage

General Description

1,4''-Bipiperidin-2-one is a chemical compound with the molecular formula C10H18N2O. It is a cyclic amide containing a piperidine ring and a ketone functional group. 1,4''-BIPIPERIDIN-2-ONE is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the manufacturing of organic compounds. 1,4''-Bipiperidin-2-one is known for its ability to act as a chiral ligand in asymmetric synthesis, and it is also used in the synthesis of heterocyclic compounds and natural products. It is important to handle this compound with caution, as it can be hazardous if not used properly.

Upstream product

• 340962-84-7 1-(1-benzylpiperidin-4-yl)-piperidin-2-one 
• 675-20-7 piperidin-2-one 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 62150-42-9 [1,4']bipyridyl-2-one 
• 4509-90-4 5-bromovaleroyl chloride 
• 50541-93-0 4-amino-1-benzylpiperidine 

Downstream Products

• 1201592-03-1 3-(2-oxo-1,4'-bipiperidinyl-1'-yl)-5-trifluoromethyl-N-(3-trifluoromethyl-phenyl)-benzamide 
• 911627-04-8 1'-[2-(4-hydroxy-phenyl)-ethyl]-[1,4']bipiperidinyl-2-one 

Relevant articles and documents

High-yielding syntheses of 1-piperidin-4-yl butyro- and valerolactams through a tandem reductive animation-lactamization (reductive lactamization)

We report a procedure for the concise and high-yielding syntheses of 1-piperidin-4-yl-substituted butyro- and valero-lactams. Beginning with 1-benzyl-4-piperidone and γ- or δ-amino esters or acids, we have effected a tandem reductive animation lactamizati

Discovery of a tetrahydropyrimidin-2(1 H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor

Coagulation enzyme factor Xa (FXa) is a particularly promising target for the development of new anticoagulant agents. We previously reported the imidazo[1,5-c]imidazol-3-one derivative 1 as a potent and orally active FXa inhibitor. However, it was found that 1 predominantly undergoes hydrolysis upon incubation with human liver microsomes, and the human specific metabolic pathway made it difficult to predict the human pharmacokinetics. To address this issue, our synthetic efforts were focused on modification of the imidazo[1,5-c] imidazol-3-one moiety of the active metabolite 3a, derived from 1, which resulted in the discovery of the tetrahydropyrimidin-2(1H)-one derivative 5k as a highly potent and selective FXa inhibitor. Compound 5k showed no detectable amide bond cleavage in human liver microsomes, exhibited a good pharmacokinetic profile in monkeys, and had a potent antithrombotic efficacy in a rabbit model without prolongation of bleeding time. Compound 5k is currently under clinical development with the code name TAK-442.

SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS

Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) or (e); R is methyl or ethyl; and Z is substituted piperidinyl.