159878-01-0 Usage
Description
(R)-Phenylmethyl [3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl]carbamate is a complex organic compound with a carbamate functional group. It is characterized by its unique molecular structure, which includes a phenylmethyl group, a 3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl moiety, and a carbamate group. (R)-Phenylmethyl [3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl]carbamate is of interest due to its potential applications in various fields, particularly in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
(R)-Phenylmethyl [3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl]carbamate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
In the chemical industry, (R)-Phenylmethyl [3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl]carbamate is used as a building block for the creation of more complex molecules. Its versatile structure makes it a valuable asset in the synthesis of a wide range of chemical products, including specialty chemicals and advanced materials.
Used in the Preparation of HIV Protease Inhibitors:
(R)-Phenylmethyl [3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl]carbamate is used as a key component in the preparation of HIV protease inhibitors, such as streptolysin. These inhibitors play a crucial role in the treatment of HIV by blocking the activity of the HIV protease enzyme, which is essential for the replication of the virus.
Used in Antibacterial Applications:
(R)-Phenylmethyl [3-chloro-2-oxo-1-[(phenylthio)methyl]-propyl]carbamate is also used in the development of antibacterial agents, specifically against Streptococcus bacteria. Its incorporation into antibacterial drugs can help combat bacterial infections and contribute to the development of new antibiotics to address the growing issue of antibiotic resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 159878-01-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,8,7 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 159878-01:
(8*1)+(7*5)+(6*9)+(5*8)+(4*7)+(3*8)+(2*0)+(1*1)=190
190 % 10 = 0
So 159878-01-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H18ClNO3S/c19-11-17(21)16(13-24-15-9-5-2-6-10-15)20-18(22)23-12-14-7-3-1-4-8-14/h1-10,16H,11-13H2,(H,20,22)
159878-01-0Relevant articles and documents
Merging lithium carbenoid homologation and enzymatic reduction: A combinative approach to the HIV-protease inhibitor Nelfinavir
Castoldi, Laura,Ielo, Laura,Hoyos, Pilar,Hernáiz, María J.,De Luca, Laura,Alcántara, Andrés R.,Holzer, Wolfgang,Pace, Vittorio
, p. 2211 - 2217 (2018)
An effective stereocontrolled synthesis of the HIV protease inhibitor Nelfinavir is reported. Two transformations were identified crucial for achieving success: the formation of a densely functionalized α-chloroketone via the homologation of a Weinreb ami
Development of a continuous process for the industrial generation of diazomethane
Proctor, Lee D.,Warr, Antony J.
, p. 884 - 892 (2013/09/06)
The development of a safe process for the industrial generation of diazomethane is described. Diazomethane is produced and consumed in a continuous process capable of generating between 50 and 60 tonnes per year whilst the maximum inventory is maintained
HIV protease inhibitors
-
, (2008/06/13)
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
