160009-35-8

Basic information

• Product Name: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate
• Synonyms: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate;4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methylthio)-5-pyriMidinecarboxylic Acid Methyl Ester
• CAS NO: 160009-35-8
• Molecular Formula: C₁₆H₁₇FN₂O₂S
• Molecular Weight: 320.3817832
• Product Categories: Amines;Aromatics;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds
• Mol File: 160009-35-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 473.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: -0.52±0.50(Predicted)
• CAS DataBase Reference: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate(160009-35-8)
• EPA Substance Registry System: Methyl 4-(4-Fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate(160009-35-8)

Safety Data

• Hazardous Substances Data: 160009-35-8(Hazardous Substances Data)

Usage

Uses

An intermediate of Rosuvastatin (R700500).

Upstream product

• 122549-26-2 methyl 2-(4-fluorophenyl)methylidene-3-oxo-4-methylpentanoate 
• 14527-26-5 2-methylisothiourea sulphate 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 459-57-4 4-fluorobenzaldehyde 
• 885100-76-5 methyl 6-(4-fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine-5-carboxylate 
• 904743-93-7 methyl 2-(4-fluorobenzoyl)-3-methoxy-3-isopropylpropenoate 

Downstream Products

• 904743-95-9 methyl 4-(4-fluorophenyl)-6-isopropyl-2-methylsulfinylpyrimidine-5-carboxylate 
• 895129-11-0 4-(4'-fluorophenyl)-6-isopropyl-2-methylthio-5-hydroxymethyl-pyrimidine 
• 799842-06-1 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylic acid methyl ester 

Relevant articles and documents

Preparation of [6-isopropyl-4 - (4-fluoro phenyl) - 2-thio-5-yl] methyl ester

The invention relates to a preparation method of a pharmaceutical chemical intermediate and particularly relates to a preparation method of [6-isopropyl-4- (4-fluorophenyl)-2-thio-5-yl]formate. According to the method, p-fluorobenzaldehyde, isobutyryl ace

PREPARATION OF ALKYL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONY)AMINO]-PYRIMIDINE-5-CARBOXYLATE AND ITS SUBSEQUENT CONVERSION TO N-[4-(4-FLUOROPHENYL)-5-FORMYL-6-ISOPROPYL PYRIMIDIN-2-YL]-N-METHYLMETHANESULFONAMIDE-A KEY INTERMEDIATE IN THE SYNTHESIS OF ROSUVASTATIN

The present invention discloses a novel process to prepare a compound of formula (IIA). By reacting a compound of formula-[D], wherein R1 is C1 to C6 alkyl, preferably R1 is methyl or ethyl, more preferably R1 is methyl ; and R2 is C1 to C8 n-alkyl or branched alkyl, cycloalkyl, phenyl , benzyl or substituted phenyl group, preferably R2 is methyl ; with N-methyl methanesulfonamide and a base, optionally with a salt of N-methyl methanesulfonamide, in suitable solvent(s) , to give a compound of formula (IIA), followed by converting compound of formula (IIA) to a compound for formula -[B], by a known process and finally converting a compound of formula (B) to a compound of formula (II), by a novel process using calcium hypochlorite / TEMPO as an oxidant.

PYRIMIDINE AND PYRIDINE DERIVATIVES USEFUL AS HMG-COA REDUCTASE INHIBITORS AND METHOD OF PREPARATION THEREOF

Compounds are provided having the following structure which are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol