16002-41-8

Basic information

• Product Name: Propanamide, N,2,2-trimethyl-N-phenyl-
• CAS NO: 16002-41-8
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Mol File: 16002-41-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Propanamide, N,2,2-trimethyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N,2,2-trimethyl-N-phenyl-(16002-41-8)
• EPA Substance Registry System: Propanamide, N,2,2-trimethyl-N-phenyl-(16002-41-8)

Safety Data

• Hazardous Substances Data: 16002-41-8(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 100-61-8 N-methylaniline 
• 873913-19-0 N-(2-iodophenyl)-N-methylpivalamide 
• 74-88-4 methyl iodide 
• 630-19-3 pivalaldehyde 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 53927-61-0 N-Methyl-N-phenyl-neopentylamin 
• 6625-74-7 N-pivaloylaniline 
• 21354-40-5 2,2-dimethyl-N-(4-methylphenyl)propanamide 
• 2739-12-0 N-methylaniline hydrochloride 
• 100-61-8 N-methylaniline 
• 73551-23-2 N,2,2-trimethyl-N-phenylpropanethioamide 
• 87995-59-3 3,3-dimethyl-1-(phenylamino)butan-2-one 
• 87995-60-6 N-(3,3-Dimethyl-2-oxobutyl)-N-phenylpivalamid 
• 630-19-3 pivalaldehyde 

Relevant articles and documents

N-Heterocyclic Carbene/Cobalt Cooperative Catalysis for the Chemo- and Regioselective C?N Bond Formation between Aldehyde and Amines/Amides

A novel methodology for the construction of various secondary (4 examples), tertiary amides (31 examples), and imides (16 examples) by a Cobalt(II) catalyzed oxidative amide coupling in aqueous media. The Co(III)-TMC was reacted with N-Heteroatom Carbene to form active catalyst Co(II)NHC-TMC in situ which involves in the coordination with Breslow's intermediate and SET for the activation of aldehyde and amides. The mechanism for activation of amide and amine differs on the basis of SET based nucleophilic addition and ligand exchange respectively. The regeneration of the catalyst was achieved using Fe(III)(EDTA)-H2O2 as oxidant. The use of Co(II)TMC-O2 was also found equally efficient in the process. The method is found regioselective for N?H activation in the presence of equally susceptible ortho-C?H bond activation. And amines were found more susceptible then the corresponding amide for the reaction.

An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst

An efficient and mild protocol has been developed for the synthesis of 2-substituted benzothiazole under solvent- and metal-free conditions using CBr4 as the catalyst. This process involves the activation of a thioamide through halogen bond formation between the sulphur atom of the thioamide and bromine atom of the CBr4 molecule. The presence of halogen-bonding interaction between N-methylthioamides and tetrabromomethane has been demonstrated with several control experiments, spectroscopic analysis and density functional theory (DFT). This methodology has a wide substrate scope for the synthesis of both 2-alkyl and 2-aryl substituted benzothiazoles.

Acyl-Directed ortho-Borylation of Anilines and C7 Borylation of Indoles using just BBr3

Indoles are privileged heterocycles found in many biologically active pharmaceuticals and natural products. However, the selective functionalization of the benzenoid moiety in indoles in preference to the more reactive pyrrolic unit is a significant challenge. Herein we report that N-acyl directing groups enable the C7-selective C?H borylation of indoles using just BBr3. This transformation shows some functional-group tolerance and notably proceeds with C6 substituted indoles. The directing group can be readily removed in situ and the products isolated as the pinacol boronate esters. Acyl-directed electrophilic borylation can be extended to carbazoles and anilines with excellent ortho selectivity. 4-amino-indoles are amenable to this process, with acyl group installation and directed electrophilic C?H borylation enabling selective formation of C5-BPin-indoles.