160107-13-1

Basic information

• Product Name: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-5-methyl-
• CAS NO: 160107-13-1
• Molecular Formula: C44H51N3O8Si
• Molecular Weight: 777.99
• Mol File: 160107-13-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-5-methyl-(160107-13-1)
• EPA Substance Registry System: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-5-methyl-(160107-13-1)

Safety Data

• Hazardous Substances Data: 160107-13-1(Hazardous Substances Data)

Upstream product

• 160107-15-3 N-benzoyl-5-methylcytidine 
• 2140-61-6 5-methylcytidine 
• 59237-68-2 2',3',5'-tri-O-benzoyl-5-methylcytidine 
• 554-01-8 5-methylcytosin 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 160107-17-5 N-(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide 
• 32865-88-6 2'-O,N⁴-bis-trimethylsilyl-5-methylcytosine 

Relevant articles and documents

Recognition of RNA by tripler formation: Divergent effects of pyrimidine C-5 methylation

In DNA triple helices, methylation at C-5 of thymine or cytosine is reported to have similar stabilizing effects for both bases. Here we show, however, that methylation of the same positions in RNA triplexes has distinctly different effects than in DNA. We have previously described the use of circular triplex-forming RNA oligonucleotides to recognize RNA sequences. Here it is shown that addition of C-5 methyl groups to uracils in these compounds very significantly increases not only affinity but also sequence selectivity in binding a purine-rich RNA target, as measured by thermal denaturation with various target RNAs. Surprisingly, however, addition of C-5 methyl groups to cytosines actually decreases affinity in binding RNA, while the same substitution in DNB is thermally stabilizing. Possible sources of this divergent behavior are discussed. A synthesis of 5-methylcytidine ribonucleoside 2'-O-silyl-3'-O-phosphoramidite is also described.