160233-42-1Relevant articles and documents
Method for catalyzing asymmetric Henry reaction of trifluoromethyl ketone
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Paragraph 0192; 0195-0196, (2021/03/06)
The invention provides a method for catalyzing asymmetric Henry reaction of trifluoromethyl ketone. The method adopts a brand-new catalyst namely a compound shown as a formula I, and is simple to operate, high in substrate universality, high in reaction y
Total synthesis and activity of the metallo-β-lactamase inhibitor aspergillomarasmine A
Koteva, Kalinka,King, Andrew M.,Capretta, Alfredo,Wright, Gerard D.
supporting information, p. 2210 - 2212 (2016/02/19)
Resistance to β-lactam antibiotics is mediated primarily by enzymes that hydrolytically inactivate the drugs by one of two mechanisms: serine nucleophilic attack or metal-dependent activation of a water molecule. Serine β-lactamases are countered in the c
Studies on the synthesis of orthogonally protected azalanthionines, and of routes towards β-methyl azalanthionines, by ring opening of N-activated aziridine-2-carboxylates
O'Brien, Keith,ó Proinsias, Keith,Kelleher, Fintan
, p. 5082 - 5092 (2014/07/08)
Orthogonally protected azalanthionines were successfully synthesised by the ring-opening of N-activated aziridine-2-carboxylates with protected diaminopropanoic acids (DAPs). The required DAPs were also prepared by ring-opening of N-activated aziridine-2-carboxylates with para- methoxybenzylamine, but it was found that the choice of aziridine protecting groups dictated both the success of the reaction as well as the regioselectivity of the isolated products. Attempts to extend the methodology to the preparation of the more sterically demanding β-methyl azalanthionines have, so far, been unsuccessful.