160237-90-1

Basic information

• Product Name: C₅₃H₆₁Cl₆NO₁₈
• Synonyms: C₅₃H₆₁Cl₆NO₁₈
• CAS NO: 160237-90-1
• Molecular Weight: 1212.78
• Mol File: 160237-90-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₃H₆₁Cl₆NO₁₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₃H₆₁Cl₆NO₁₈(160237-90-1)
• EPA Substance Registry System: C₅₃H₆₁Cl₆NO₁₈(160237-90-1)

Safety Data

• Hazardous Substances Data: 160237-90-1(Hazardous Substances Data)

Upstream product

• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 160237-89-8 (4S,5S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-acetic acid 

Downstream Products

• 160237-93-4 C₅₀H₅₇Cl₆NO₁₈ 
• 160237-92-3 10-deacetyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>-1a'-homotaxol 
• 160237-91-2 10-deacetyl-3'-N-debenzoyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>-1a'-homotaxol 

Relevant articles and documents

Structure-activity studies of antitumor taxanes: Synthesis of novel C-13 side chain homologated taxol and taxotere analogs

Taxol and taxotere analogs with one carbon homologated side chains were synthesized from 10-deacetylbaccatin III and a key oxazolidineacetic acid intermediate, which was synthesized in four steps from (S)-(+)-2- phenylglycine. 10-Deacetyl-1a'-homotaxol and 1a'-homotaxotere were at least 27 times less active than taxol in the microtubule assembly assay. The inability of these homologs to induce microtubule formation may be due to unfavorable solution conformations, preventing productive interactions with the taxol binding site on microtubules.