16031-54-2

Basic information

• Product Name: Cyclopropanol, 1-(4-chlorophenyl)-
• CAS NO: 16031-54-2
• Molecular Formula: C9H9ClO
• Molecular Weight: 168.623
• Mol File: 16031-54-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Cyclopropanol, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanol, 1-(4-chlorophenyl)-(16031-54-2)
• EPA Substance Registry System: Cyclopropanol, 1-(4-chlorophenyl)-(16031-54-2)

Safety Data

• Hazardous Substances Data: 16031-54-2(Hazardous Substances Data)

Usage

Description

Cyclopropanol, 1-(4-chlorophenyl)is a chemical compound characterized by the presence of a cyclopropane ring and a 4-chlorophenyl group. This colorless liquid is primarily utilized in the synthesis of other organic compounds and may have potential applications in the pharmaceutical industry as a building block for drug production or in the development of new materials.
Used in Pharmaceutical Industry:
Cyclopropanol, 1-(4-chlorophenyl)is used as a building block for the production of drugs due to its unique chemical structure, which can be incorporated into various pharmaceutical compounds to enhance their properties or create new therapeutic agents.
Used in Chemical Synthesis:
Cyclopropanol, 1-(4-chlorophenyl)is used as an intermediate in the synthesis of other organic compounds, contributing to the development of new materials and chemical products.
Used in Material Development:
Cyclopropanol, 1-(4-chlorophenyl)is used in the development of new materials, potentially offering unique properties or improvements over existing materials due to its distinct chemical structure.
It is important to handle Cyclopropanol, 1-(4-chlorophenyl)with caution, as it can be flammable and may have harmful effects if not used properly. Despite these considerations, its potential uses in various industries highlight its contribution to the advancement of new compounds and materials.

Upstream product

• 7270-47-5 4-chlorophenylmagnesium iodide 
• 534-07-6 1,3-Dichloroacetone 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 925-90-6 ethylmagnesium bromide 
• 2386-64-3 ethylmagnesium chloride 
• 99-91-2 para-chloroacetophenone 
• 58518-76-6 ((1-(4-chlorophenyl)vinyl)oxy)trimethylsilane 
• 66267-02-5 [1-(4-Chloro-phenyl)-cyclopropoxy]-trimethyl-silane 
• 106-46-7 para-dichlorobenzene 
• 5009-27-8 cyclopropanone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-39-8 bromochlorobenzene 
• 7335-27-5 ethyl 4-chlorobenzoate 

Downstream Products

• 1339700-52-5 1-(4'-chlorophenyl)-4,4,4-trifluoro-1-butanone 

Relevant articles and documents

Iron-Catalyzed Ring-Opening Reactions of Cyclopropanols with Alkenes and TBHP: Synthesis of 5-Oxo Peroxides

The ring opening of cyclopropanols is rarely used in multicomponent reactions. Herein we report the three-component reaction of cyclopropanols with alkenes and tert-butyl hydroperoxide (TBHP) catalyzed by an iron catalyst. This protocol enables the incorporation of both the β-carbonyl fragment and a peroxy unit across the C=C double bond regioselectively, thus allowing an efficient, facile access to 5-oxo peroxides. Modification of the biologically active molecules and various downstream derivatizations of the peroxides are also demonstrated.

Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones

The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.

Aryl Pyrazoles from Photocatalytic Cycloadditions of Arenediazonium

A photocatalytic synthesis of 1,5-diaryl pyrazoles from arenediazoniums and arylcyclopropanols is reported. The reaction proceeded under mild conditions (rt, 20 min) with catalytic [Ru(bpy)3]2+ under blue-light irradiation and exhibited compatibility with several functional groups (e.g., I, SF5, SO2NH2, N3, CN) and perfect levels of regiocontrol. Mechanistic studies (luminescence spectroscopy, CV, DFT, radical trapping, quantum yield determination) documented an initial oxidative quenching of the excited photocatalyst and the operation of a radical-chain mechanism.