1603108-18-4Relevant articles and documents
Synthesis, antibiotic activity and structure-activity relationship study of some 3-enaminetetramic acids
Jeong, Yong-Chul,Anwar, Muhammad,Moloney, Mark G.
, p. 1901 - 1906 (2014)
The synthesis and evaluation of 3-enaminetetramic acids as antibacterial agents is reported; contrary to the analogous 3-acyltetramic acids, the enaminetetramic acid class of compound exhibits modest antibacterial activity against a limited spectrum of organisms, and even that activity is strongly dependent on the identity of the tetramate ring substituents. Moreover, these compounds appear to have a different mode of action to the analogous 3-acyltetramic acids, and appear to offer more limited opportunity for further elaboration in drug discovery.
