160322-88-3

Basic information

• Product Name: 6-[2-(3,4-Dimethoxy-benzyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one
• Synonyms: 6-[2-(3,4-Dimethoxy-benzyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one
• CAS NO: 160322-88-3
• Molecular Weight: 380.467
• Mol File: 160322-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[2-(3,4-Dimethoxy-benzyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[2-(3,4-Dimethoxy-benzyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one(160322-88-3)
• EPA Substance Registry System: 6-[2-(3,4-Dimethoxy-benzyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one(160322-88-3)

Safety Data

• Hazardous Substances Data: 160322-88-3(Hazardous Substances Data)

Upstream product

• 61122-82-5 6-chloroacetyl-1,2,3,4-tetrahydroquinolin-2-one 
• 145736-65-8 3,4-Dimethoxyphenylthioacetamid 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 

Downstream Products

• 145737-92-4 6-[2-(3,4-Dimethoxy-benzoyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4- diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure- activity relationships of these compounds are reported herein.