16074-59-2

Basic information

• Product Name: 4H-1-Benzopyran-4-thione, 2-(4-methylphenyl)-
• CAS NO: 16074-59-2
• Molecular Formula: C16H12OS
• Molecular Weight: 252.337
• Mol File: 16074-59-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-thione, 2-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-thione, 2-(4-methylphenyl)-(16074-59-2)
• EPA Substance Registry System: 4H-1-Benzopyran-4-thione, 2-(4-methylphenyl)-(16074-59-2)

Safety Data

• Hazardous Substances Data: 16074-59-2(Hazardous Substances Data)

Upstream product

• 5067-22-1 1-(2-hydroxyphenyl)-3-(4-methylphenyl)propane-1,3-dione 
• 34000-27-6 1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one 
• 874-60-2 4-methyl-benzoyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 41255-30-5 4'-methylflavone 

Downstream Products

• 41255-30-5 4'-methylflavone 
• 63645-50-1 C₁₈H₁₅NO₃ 
• 63645-49-8 2-p-Tolyl-chromen-4-one oxime 

Relevant articles and documents

Structure activity relationship studies of some potent antifungal flavones, 4-thioflavones and 4-iminoflavones

A series of flavones, carrying halogens, methoxy and nitro groups at various positions were synthesized by the Baker-Venkataraman rearrangement and were subsequently converted to 4-thioflavones and 4-iminoflavones. The synthesized compounds were evaluated for their in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. All synthesized compounds showed significant activity against T. longusus, A. flavus, M. canis and F. Solani but inactive against C. albicans and C. glabrata, respectively. 2-phenyl-4H-1-benzopyran-4-thiones were relatively more active than flavones and 4-iminoflavones. However, some compounds were even more active than standard miconazol and amphotericin B drugs.

A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors

A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.

A facile and cheap method for the conversion of flavones into 4-thioflavones using phosphorus pentasulfide and sodium hydrogen carbonate

A facile, rapid, high yielding and relatively cheaper method has been developed for the synthesis of 4-thioflavones by using phosphorus pentasulfide and sodium hydrogen carbonate. Seven new and five known substituted 4-thioflavones prepared by this method are reported.