16077-10-4

Basic information

• Product Name: 1-benzyl-5-methoxyindoline-2,3-dione
• Synonyms: 1-benzyl-5-methoxyindoline-2,3-dione;1H-Indole-2,3-dione, 5-methoxy-1-(phenylmethyl)-;1-benzyl-5-methoxyindoline-2,3-dione(WXC05186);1-BENZYL-5-METHOXY-2,3-DIHYDRO-1H-INDOLE-2,3-DIONE
• CAS NO: 16077-10-4
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267.27932
• Mol File: 16077-10-4.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzyl-5-methoxyindoline-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-5-methoxyindoline-2,3-dione(16077-10-4)
• EPA Substance Registry System: 1-benzyl-5-methoxyindoline-2,3-dione(16077-10-4)

Safety Data

• Hazardous Substances Data: 16077-10-4(Hazardous Substances Data)

Usage

Molecular Class

Indole derivatives

Biological Activities

Anti-inflammatory, antioxidant, and neuroprotective effects

Potential Applications

Organic synthesis, medicinal chemistry, and development of new drugs for neurological disorders

Common Use

Intermediate for the synthesis of pharmaceutical compounds

Upstream product

• 39755-95-8 5-methoxyisatine 
• 100-39-0 benzyl bromide 
• 1426840-39-2 C₁₆H₁₆BrNO₂ 
• 100-44-7 benzyl chloride 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 65836-82-0 1-benzyl-2,3-dihydro-5-methoxy-1H-indol-2-one 
• 1229649-03-9 3-allyl-1-benzyl-3-hydroxy-5-methoxy-2-oxo-2,3-dihydroindole 
• 1246886-63-4 C₁₉H₁₇NO₄ 
• 1345838-27-8 (2'R,3'R)-ethyl 1-benzyl-5-methoxy-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate 
• 1345838-28-9 (2'S,3'R)-ethyl 1-benzyl-5-methoxy-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate 
• 1190109-49-9 (S)-3-allyl-1-benzyl-3-hydroxy-5-methoxyindolin-2-one 
• 1526920-78-4 (2'R,3'R)-1-benzyl-4',5-dimethoxy-3'-methylspiro[indoline-3,2'-pyran]-2,6'(3'H)-dione 
• 1590380-24-7 1-ethyl 3-methyl 6-benzyl-9-methoxy-2-methyl-5-oxo-5,6-dihydropyrrolo[1,2-c]quinazoline-1,3-dicarboxylate 
• 1568924-78-6 (R)-tert-butyl (1-benzyl-3-(diphenoxyphosphoryl)-5-methoxy-2-oxoindolin-3-yl)carbamate 
• 1426931-92-1 tert-butyl (1-benzyl-5-methoxy-2-oxoindolin-3-ylidene)carbamate 

Relevant articles and documents

Applications of Ytterbium(II) Reagent as Grignard Reagent and Single-Electron Transfer Reagent in the Synthesis of 3-Substituted 2-Oxindoles

The use of ytterbium(II) reagent as both nucleophilic reagent and single-electron transfer reagent in the reaction of isatin derivatives with ytterbium(II) reagent is reported. From a synthetic point of view, a general, efficient, and experimentally simple one-pot method for the preparation of 3-substituted 2-oxindoles was developed.

Dynamic Kinetic Asymmetric Transformation of Racemic Diastereomers: Diastereo- and Enantioconvergent Michael–Henry Reactions to Afford Spirooxindoles Bearing Furan-Fused Rings

Dynamic kinetic asymmetric transformation (DYKAT) reactions of racemic diastereomer mixtures that afford the products as essentially single diastereomers with high enantioselectivities are described. We demonstrated the DYKAT in the diastereo- and enantio

Reductive aromatization of oxindoles to 3-substituted indoles

A practical and scalable approach for the synthesis of 3-substituted indoles is delineated via hydride nucleophilic addition to 3-substituted-2-oxindoles. The reaction proceeds through reductive aromatization involving indolinium ion intermediate. A wide range of 3-functionalized indoles have been synthesized. The method is employed for the synthesis of 3,3?-bis-indoles and a dimeric 3-indole derivative. Moreover, this protocol is used to obtain naturally occuring amino acid tryptamine.