1608-93-1Relevant articles and documents
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Raunio,E.K.,Remsberg,L.P.
, p. 1436 - 1437 (1960)
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Scalable synthetic oligodeoxynucleotide purification with use of a catching by polymerization, washing, and releasing approach
Fang, Shiyue,Fueangfung, Suntara
, p. 3720 - 3723 (2010)
Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides.
A novel synthesis of γ,δ-unsaturated aldehydes from α-formyl-γ-lactones
Snowden, Roger L.,Brauchli, Robert,Linder, Simon
experimental part, p. 1216 - 1225 (2011/09/16)
A preparatively useful one-step transformation of γ,γ- disubstituted α-formyl-γ-lactones into trisubstituted γ,δ-unsaturated aldehydes is described, by means of catalytic amounts of either AcOH or AcOEt in the vapor phase over a glass support. A mechanistic rationale is proposed. Copyright
Synthesis of new furan derivatives and 4-hydroxy aldehydes from 4-hydroxy 1-enol ethers
Hoelemann, Alexandra,Reissig, Hans-Ulrich
, p. 1963 - 1970 (2007/10/03)
Starting from 4-hydroxy 1-enol ethers 3 different γ-lactols 4 were successfully prepared by acidic hydrolysis. Subsequent oxidation of 4 with pyridinium chlorochromate (PCC) led to γ-lactones 6 in good to excellent overall yields. Treatment of γ-lactols 4