160812-25-9Relevant articles and documents
A Short Synthesis of Vicine and Convicine, the Causative Agents of Favism
Kunesch, Nicole,Miet, Christine,Poisson, Jacques
, p. 1059 - 1064 (2007/10/02)
Vicine (1) and convicine (2) (Vicia faba), causative of the human disease favism, have been conveniently prepared in good yields by a three-step synthesis starting from ethyl glyoxylate.The key step is the reaction of a suitable tetra-O-acetylglucopyranoside with a large excess of guanidine with causes simultaneously deacetylation and coupling. - Key Words: Vicine / Convicine / Favism / Pyrimidines, 5-hydroxy- / Glycosides / Carbohydrates / Trichloroacetimidates