16082-00-1Relevant articles and documents
Synthesis and biological evaluation of quinazoline-4-thiones
Kubicova, Lenka,Sustr, Martin,Kral'ova, Katarina,Chobot, Vladimir,Vytlacilova, Jitka,Jahodar, Ludek,Vuorela, Pia,Machacek, Milos,Kaustova, Jarmila
, p. 756 - 769 (2007/10/03)
Several 2,2-dimethyl-3-phenyl-1,2-dihydroquinazoline-4(3H)-thiones and 2-methyl-3-phenylquinazoline-4(3H)-thiones were synthesized and tested for their antimycobacterial, photosynthesis-inhibiting, and antialgal activity. Antimycobacterially active compounds were found among the 6-chloro substituted compounds. 6-Chloro-3-(4-isopropylphenyl)-2-methylquinazoline-4(3H)-thione exhibited higher activity than the isoniazid standard against Mycobacterium avium and M. kansasii. Most of the compounds possessed photosynthesis-inhibiting activity. 6-Chloro-2,2-dimethyl-3-phenyl-1,2-dihydro-quinazoline-4(3H)-thione and its 3′-chloro- and 3′,4′-dichloro analogs were most effective in the inhibition of oxygen evolution rate in spinach chloroplasts. Of compounds selected for toxicological screening, 6-chloro-3-(4-isopropylphenyl)- 2-methyl-quinazoline-4(3H)-thione was the only one active in the brine shrimp bioassay.
