160855-15-2Relevant articles and documents
Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification
Lai, Hai-Wang,Liu, Zai-Qun
, p. 227 - 236 (2014/06/09)
4-Thiaflavan is a sulfur-substituted flavonoid with a benzoxathiin scaffold. The aim of this work is to compare abilities of sulfur and oxygen atom, hydroxyl groups, and ferrocene moiety at different positions of 4-thiaflavan to trap radicals and to inhibit DNA oxidation. It is found that abilities of thiaflavans to trap radicals and to inhibit DNA oxidation are increased in the presence of ferrocene moiety and are further improved by the electron-donating group attaching to thiaflavan skeleton. It can be concluded that the ferrocene moiety plays the major role for thiaflavans to be antioxidants even in the absence of phenolic hydroxyl groups. On the other hand, the antioxidant effectiveness of phenolic hydroxyl groups in thiaflavans can be improved by the electron-donating group. The influences of sulfur and oxygen atoms in thiaflavans on the antioxidant property of para-hydroxyl group exhibit different manners when the thiaflavans are used to trap radicals and to inhibit DNA oxidation.
Phthalimidesulfenyl Chloride Part 8. Reaction with Activated Arenes: the First Example of ortho-Thioquinones Generation
Capozzi, Giuseppe,Menichetti, Stefano,Nativi, Cristina,Simonti, Maria Cristina
, p. 9451 - 9454 (2007/10/02)
Phthalimidesulfenyl chloride 1 reacts with activated arenes 2a-g, to give monosubstituted derivatives 3a-g.Hydroxysulfenyl compounds 3a-d have been used as suitable source of α-oxothiones (ortho-thioquinones) 4a-d, which act as heterodienes in 4 + 2 cyclo