160905-87-3

Basic information

• Product Name: Guanosine, N-[(dimethylamino)methylene]-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-
• CAS NO: 160905-87-3
• Molecular Formula: C29H36N6O5Si
• Molecular Weight: 576.728
• Mol File: 160905-87-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Guanosine, N-[(dimethylamino)methylene]-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine, N-[(dimethylamino)methylene]-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(160905-87-3)
• EPA Substance Registry System: Guanosine, N-[(dimethylamino)methylene]-5'-O-[(1,1-dimethylethyl)diphenylsilyl]-(160905-87-3)

Safety Data

• Hazardous Substances Data: 160905-87-3(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 17331-16-7 N²-(dimethylaminomethylene)guanosine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 75054-94-3 5'-O-(tert-butyldiphenylsilyl)guanosine 
• 118-00-3 G 

Downstream Products

• 329014-12-2 9-(2'-O-acetyl-5'-O-tert-butyldiphenylsilyl-3'-β-D-2-(N',N'-dimethylaminomethylene) xylofuranosyl) guanine 
• 869355-04-4 N'-[9-((2R,3R,5S)-3-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine 
• 557771-61-6 2'-O-[(benzylamino)carbonyl]-3'-bromo-5'-O-[(tert-butyl)diphenylsilyl]-3'-deoxy-2-[(dimethylamino)methylidene]guanosine 
• 557771-60-5 3'-bromo-5'-O-[(tert-butyl)diphenylsilyl]-3'-deoxy-2-[(dimethylamino)methylidene]guanosine 
• 557771-62-7 3'-(benzylamino)-2'-O,3'-N-carbonyl-3'-deoxy-2-[(dimethylamino)methylidene]guanosine 
• 557771-63-8 3'-(benzylamino)-3'-deoxyguanosine 
• 80015-76-5 9-(3-Amino-3-desoxy-β-D-ribofuranosyl)guanin 
• 247223-54-7 9-(2'-O-acetyl-3'-bromo-5'-O-tert-butyldiphenylsilyl-3'-deoxy-β-D-xylofuranosyl)-2-N-(N',N'-dimethylaminomethylene) guanine 
• 160905-88-4 5'-O-(tert-butyldiphenylsilyl)-2-N-dimethylaminomethylene-2',3'-di-O-laevulinylguanosine 

Relevant articles and documents

Stereoselective and Divergent Aza-Adenosine and Aza-Guanosine Syntheses from Xylofuranose, the Key Fragments of a STING Cyclic Dinucleotide Agonist

The stereoselective and divergent synthesis of two aza-nucleosides is reported. Starting from xylofuranose 9, aza-adenosine 2 was prepared in 13 steps and 7% overall yield, and aza-guanosine 3 was prepared in 13 steps and 7.8% overall yield. Compared to t

SYNTHETIC PGPG ANALOGS, METHODS OF PREPARATION AND METHODS OF USE

The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, and L are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating and preventing bacterial infections, and methods of identifying pGpG-binding domains in bacteria, using the compounds of Formula I.

Efficient synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine from adenosine and guanosine

Highly efficient synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine from adenosine and guanosine were described. The 2′,3′-diol of protected adenosine and guanosine were reacted with α-acetoxyisobutyryl bromide to yield 9-(2′-O-acetyl-3′-bromo