16091-98-8Relevant articles and documents
A novel method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid
Pan, Xianhua,Lu, Qingling,Li, Xiaojun,Zhang, Jianshui,Yu, Wansheng,Liu, Feng
, p. 722 - 723 (2013)
A simple and efficient synthetic route to 2-(3-hydroxy-1-adamantyl)-2- oxoacetic acid is described by a direct oxidation reaction of adamantan-1-yl-ethan-1-one which could be prepared by a Grignard reaction. In this approach, the oxidation reaction introduced the hydroxyl and carboxyl group by a one-pot reaction.
Eliminative Ring Fission of 1,2,4-Trioxan-5-ones. A New Approach to α-Keto Acids
Jefford, Charles W.,Rossier, Jean-Claude,Boukouvalas, John
, p. 1701 - 1702 (2007/10/02)
6-Mono-R-substituted 1,2,4-trioxan-5-ones readily undergo base-catalysed O-O bond cleavage to furnish α-keto acids (RCOCOOH) in high yields even when the R-substituents are bulky.