1609486-08-9Relevant articles and documents
Copper-catalyzed cross-coupling of vinylsiloxanes with bromoalkynes: Synthesis of enynes
Cornelissen, Loic,Lefrancq, Maxime,Riant, Olivier
supporting information, p. 3024 - 3027 (2014/06/23)
Enynes are versatile building blocks in organic synthesis. A copper-catalyzed Hiyama-type cross-coupling of vinylsiloxanes with bromoalkynes is presented. This mild and efficient method led to the formation of various sensitive enynes. The use of cis, trans, and 1,1′-disubstituted vinylsiloxanes was allowed, and full retention of stereochemistry was observed. Sensitive groups such as halides, unsaturated ketones, and aldehydes were fully tolerated.