1609558-86-2Relevant articles and documents
A versatile annulation route to primary-amino-substituted naphthyridine esters
Chen, Jinhua,Xu, Zijin,Wang, Tao,Lyssikatos, Joseph P.,Ndubaku, Chudi O.
, p. 89 - 92 (2014/01/06)
A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyano-pyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of -primary-amino-substituted 7-azaquinoxaline was also described. Georg Thieme Verlag Stuttgart · New York.
