1609644-39-4

Basic information

• Product Name: C₂₀H₂₄F₂N₂O₃
• Synonyms: C₂₀H₂₄F₂N₂O₃
• CAS NO: 1609644-39-4
• Molecular Weight: 378.419
• Mol File: 1609644-39-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₄F₂N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₄F₂N₂O₃(1609644-39-4)
• EPA Substance Registry System: C₂₀H₂₄F₂N₂O₃(1609644-39-4)

Safety Data

• Hazardous Substances Data: 1609644-39-4(Hazardous Substances Data)

Upstream product

• 453-14-5 1,3-difluoro-propan-2-one 
• 1609644-25-8 2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide 
• 1609644-58-7 tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate 

Downstream Products

• 1081548-91-5 (1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol 

Relevant articles and documents

MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE

Described herein are monobactam antibiotics of Formula (I), (Ι'), (II), and (II'), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also p

Stereocontrolled synthesis of syn-β-hydroxy-α-amino acids by direct aldolization of pseudoephenamine glycinamide

β-Hydroxy-α-amino acids figure prominently as chiral building blocks in chemical synthesis and serve as precursors to numerous important medicines. Reported herein is a method for the synthesis of β-hydroxy- α-amino acid derivatives by aldolization of pseudoephenamine glycinamide, which can be prepared from pseudoephenamine in a one-flask protocol. Enolization of (R,R)- or (S,S)-pseudoephenamine glycinamide with lithium hexamethyldisilazide in the presence of LiCl followed by addition of an aldehyde or ketone substrate affords aldol addition products that are stereochemically homologous with L- or D-threonine, respectively. These products, which are typically solids, can be obtained in stereoisomerically pure form in yields of 55-98 %, and are readily transformed into β-hydroxy-α-amino acids by mild hydrolysis or into 2-amino-1,3-diols by reduction with sodium borohydride. This new chemistry greatly facilitates the construction of novel antibiotics of several different classes. On aldol: Enolization of (R,R)- or (S,S)-pseudoephenamine glycinamide with lithium hexamethyldisilazide (LiHMDS) in the presence of LiCl followed by addition of either an aldehyde or ketone substrate affords aldol addition products which are stereochemically homologous with L- or D-threonine, respectively. These products can be obtained in stereoisomerically pure form in yields of 55-98 %, and are readily transformed into β-hydroxy-α-amino acids by mild hydrolysis or into 2-amino-1,3-diols by reduction.