160999-36-0

Basic information

• Product Name: (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine
• Synonyms: (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine
• CAS NO: 160999-36-0
• Molecular Weight: 354.452
• Mol File: 160999-36-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine(160999-36-0)
• EPA Substance Registry System: (2S,5R)-2-<(1-Benzylimidazol-5-yl)methyl>-2,5-dihydro-3,6-dimethoxy-5-isopropylpyrazine(160999-36-0)

Safety Data

• Hazardous Substances Data: 160999-36-0(Hazardous Substances Data)

Upstream product

• 160999-35-9 1-Benzyl-5-(2-phenylethenyl)-1H-imidazole 
• 85102-99-4 1-benzyl-1H-imidazole-5-carboxaldehyde 
• 60293-41-6 N-((E)-3-phenylallylidene)benzylamine 
• 80304-50-3 1-benzyl-5-hydroxymethylimidazole 
• 109838-85-9 (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine 
• 82830-36-2 1-Benzyl-5-(chloromethyl)-1H-imidazolium chloride 

Downstream Products

• 1007-42-7 L-Histidine dihydrochloride 

Relevant articles and documents

Synthesis of L-histidine specifically labelled with stable isotopes

(2'-13C)-, (1'-15N)- and (3'-15N)-L-Histidine were prepared according to a synthetic scheme that allows the 13C or 15N labelling of all carbon and nitrogen positions or any combination of positions.A 1,5-disubstituted imidazole ring was constructed via condensation of tosylmethyl isocyanide with 3-phenylpropenal and subsequent cycloaddition of benzylamine.The imidazole intermediate was converted into 1-benzyl-5-(chloromethyl)-imidazolium chloride which was coupled to a glycine moiety via an enantioselective coupling with the bislactim ether of cyclo-D-valylglycine.Deprotection of the coupling product afforded L-histidine in high optical purity.Syntheses for the isotopically labelled synthons were developed starting from simple, comercially available, highly enriched compounds.The labelled L-histidines were characterized by mass spectrometry and 1H-, 13C- and 15N-NMR spectroscopy.