1610-04-4

Basic information

• Product Name: 2-BROMO-2,2-DIFLUORO-1-PHENYL-ETHANONE
• Synonyms: 2-BROMO-2,2-DIFLUORO-1-PHENYL-ETHANONE
• CAS NO: 1610-04-4
• Molecular Formula: C₈H₅BrF₂O
• Molecular Weight: 235.0255064
• Mol File: 1610-04-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 206.7°C at 760 mmHg
• Flash Point: 78.8°C
• Appearance: /
• Density: 1.619g/cm³
• Vapor Pressure: 0.234mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 2-BROMO-2,2-DIFLUORO-1-PHENYL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-2,2-DIFLUORO-1-PHENYL-ETHANONE(1610-04-4)
• EPA Substance Registry System: 2-BROMO-2,2-DIFLUORO-1-PHENYL-ETHANONE(1610-04-4)

Safety Data

• Hazardous Substances Data: 1610-04-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H5BrF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H

Upstream product

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Downstream Products

• 434-45-7 2,2,2-Trifluoroacetophenone 

Relevant articles and documents

Merging Visible Light with Cross-Coupling: The Photochemical Direct C-H Difluoroalkylation of Imidazopyridines

A transition-metal-free protocol for the difluoroalkylation of imidazopyridines with bromodifluoroaryl ketones promoted by visible light irradiation is presented. This protocol is distinguished by simple, mild, and catalyst-free reaction conditions with a

CF2DSO2Na: An Effective Precursor Reagent for Deuteriodifluoromethylthiolation and Deuteriodifluoromethylation

Deuteriodifluoromethythio (SCF2D) and deuteriodifluoromethyl (CF2D) are important functional groups in pharmaceutical and agrochemical compounds, and the introduction of these functional groups remains a challenging. We herein report a robust reagent for deuteriodifluoromethylthiolation and deuteriodifluoromethylation. Its potentials were successfully showcased by deuteriodifluoromethylation and deuteriodifluoromethylthiolation of indoles with high-level deuterium incorporation. The reagent also has potential for deuteriodifluoromethylation and deuteriodifluoromethylthiolation of wide range of other natural or synthetic bioactive molecules.

Copper-Catalyzed Fluoroolefination of Silyl Enol Ethers and Ketones toward the Synthesis of β-Fluoroenones

A general and facile synthetic method for β-fluoroenones from silyl enol ethers or ketones, with a copper-amine catalyst system, has been developed. The reaction proceeded by a tandem process of difluoroalkylation-hydrolysis-dehydrofluorination. This method is characterized by high yields, excellent Z/E ratios, a low-cost catalyst, and a broad substrate scope. The synthetic potential of β-fluoroenones has been demonstrated by the construction of various complicated organofluorine molecules.